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豚鼠子宫内膜分泌的自主神经控制

Autonomic nervous control of endometrial secretion in the guinea pig.

作者信息

Hammarström M

出版信息

Acta Physiol Scand. 1985 Nov;125(3):461-9. doi: 10.1111/j.1748-1716.1985.tb07743.x.

DOI:10.1111/j.1748-1716.1985.tb07743.x
PMID:2867665
Abstract

Secretory responses of the guinea pig endometrium to field stimulation of nerves and/or drugs were studied throughout oestrous cycle. Secretory responses are dependent on the hormonal state of the animals and are seen at oestrus, metoestrus and at implantation time. The cholinergic nature of the secretory innervation was confirmed. Optimal secretory response was found at 0.5 or 1 Hz continuous stimulation. Adrenergic inhibition was revealed at metoestrus (day 3-5), The alpha-adrenergic inhibitory influence had its optimal frequency at 0.5 Hz. The inhibition seemed to be both prejunctional and postjunctional. VIP increased endometrial secretion, the effect was probably preterminal. Burst stimulation at any frequency gave less (or no) secretory responses under these experimental conditions. The complex organization of the endometrial innervation is apparent.

摘要

在整个发情周期中,研究了豚鼠子宫内膜对神经和/或药物的场刺激的分泌反应。分泌反应取决于动物的激素状态,在发情期、发情后期和着床期可见。证实了分泌神经支配的胆碱能性质。在0.5或1Hz连续刺激下发现了最佳分泌反应。在发情后期(第3 - 5天)发现了肾上腺素能抑制作用,α-肾上腺素能抑制作用在0.5Hz时有最佳频率。这种抑制似乎是节前和节后的。血管活性肠肽增加子宫内膜分泌,其作用可能是终末前的。在这些实验条件下,任何频率的爆发刺激产生的分泌反应较少(或没有)。子宫内膜神经支配的复杂组织是明显的。

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