Hammarström M
Department of Physiology I, Karolinska Institutet, Sweden.
Acta Physiol Scand. 1989 Mar;135(3):367-71. doi: 10.1111/j.1748-1716.1989.tb08589.x.
Neurogenic influence on cervical secretion was studied in experiments performed on isolated guinea-pig cervix with intact adjacent nerves. The secretion was estimated as carbohydrate efflux. Experiments were undertaken at ovulation time when secretion is most prominent. Hypogastric nerve stimulation significantly increased carbohydrate release. This response was unaffected by phentolamine but inhibited by TTX, scopolamine and hexamethonium, as well as previous destruction of paracervical ganglia. Pelvic nerve stimulation did not affect cervical secretion. Carbachol as well as VIP induced a secretory response of the same extent as did hypogastric nerve stimulation. Scopolamine abolished the VIP-induced secretion. VIP and carbachol in combination had no additive effect. It is concluded that cervical glands of the guinea-pig uterus possess a cholinergic secretomotor innervation. The main pathway is the hypogastric nerve and neurons have a peripheral relay at paracervical ganglia. A more complex peripheral organization cannot be excluded.
在对具有完整相邻神经的豚鼠离体子宫颈进行的实验中，研究了神经源性对子宫颈分泌的影响。分泌量以碳水化合物流出量来估算。实验在排卵时进行，此时分泌最为显著。刺激腹下神经可显著增加碳水化合物释放。该反应不受酚妥拉明影响，但受河豚毒素、东莨菪碱和六甲铵抑制，以及先前子宫颈旁神经节的破坏也可抑制。刺激盆神经不影响子宫颈分泌。卡巴胆碱以及血管活性肠肽诱导的分泌反应程度与刺激腹下神经相同。东莨菪碱消除了血管活性肠肽诱导的分泌。血管活性肠肽和卡巴胆碱联合使用没有相加作用。得出的结论是，豚鼠子宫的子宫颈腺具有胆碱能分泌运动神经支配。主要途径是腹下神经，神经元在子宫颈旁神经节有外周中继。不能排除更复杂的外周组织。
