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豚鼠子宫内膜胆碱能分泌神经支配的证据。

Evidence for a cholinergic secretory innervation of the guinea-pig endometrium.

作者信息

Hammarström M, Sjöstrand N O

出版信息

Acta Physiol Scand. 1979 May;106(1):11-5. doi: 10.1111/j.1748-1716.1979.tb06363.x.

DOI:10.1111/j.1748-1716.1979.tb06363.x
PMID:463574
Abstract

Uterine mucus secretion was studied by measuring carbohydrate release from everted guinea-pig uteri placed in organ baths. Field stimulation of the organ resulted in a significant increase in carbohydrate out-put, this increase was inhibited by tetrodotoxin, scopolamine and previous destruction of the paracervical ganglia. Previous section of the hypogastric nerve reduced the response to field stimulation, while interruption of the costouterine connexion or the pelvic nerve was without overt effect. Stimulation of the hypogastric nerve increased uterine carbohydrate secretion. Pelvic nerve stimulation produced no significant effect. Carbachol increased the carbohydrate secretion to the same extent as did field stimulation. Isoprenaline and methoxamine were without significant effect. It is suggested that certain endometrial cells have a cholinergic sympathetic secretory innervation with pre- and postganglionic fibers running in the hypogastric nerve.

摘要

通过测量置于器官浴槽中的外翻豚鼠子宫释放的碳水化合物,对子宫黏液分泌进行了研究。对器官进行场刺激导致碳水化合物输出显著增加,这种增加受到河豚毒素、东莨菪碱以及先前子宫颈旁神经节破坏的抑制。先前切断腹下神经会降低对场刺激的反应,而切断子宫体旁连接或盆神经则没有明显影响。刺激腹下神经会增加子宫碳水化合物分泌。刺激盆神经没有显著影响。卡巴胆碱增加碳水化合物分泌的程度与场刺激相同。异丙肾上腺素和甲氧明没有显著影响。提示某些子宫内膜细胞具有胆碱能交感分泌神经支配,节前和节后纤维走行于腹下神经中。

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引用本文的文献

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The bovine tubouterine junction: general innervation pattern and distribution of adrenergic, cholinergic, and peptidergic nerve fibers.牛输卵管子宫结合部:神经支配总体模式及肾上腺素能、胆碱能和肽能神经纤维的分布
Cell Tissue Res. 1993 Dec;274(3):493-501. doi: 10.1007/BF00314546.
2
Cholinergic nerves in mouse uterus.小鼠子宫中的胆碱能神经。
J Neural Transm. 1982;55(2):139-48. doi: 10.1007/BF01243756.
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S-100-immunoreactive nerves in the guinea-pig uterus with reference to ultrastructural correlations: effects of chemical sympathectomy and pregnancy.
Cell Tissue Res. 1987 Nov;250(2):241-9. doi: 10.1007/BF00219068.
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Protein gene product 9.5 (PGP 9.5). A new neuronal marker visualizing the whole uterine innervation and pregnancy-induced and developmental changes in the guinea pig.
Histochemistry. 1988;90(1):9-17. doi: 10.1007/BF00495700.
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Organization of the guinea-pig uterine innervation. Distribution of immunoreactivities for different neuronal markers. Effects of chemical- and pregnancy-induced sympathectomy.豚鼠子宫神经支配的组织学。不同神经元标志物免疫反应性的分布。化学性和妊娠诱导的交感神经切除术的影响。
Histochem J. 1988 May;20(5):290-300. doi: 10.1007/BF01745608.
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Co-existence and origin of peptidergic and adrenergic nerves in the guinea pig uterus. Retrograde tracing and immunocytochemistry, effects of chemical sympathectomy, capsaicin treatment and pregnancy.豚鼠子宫中肽能神经与肾上腺素能神经的共存及起源。逆行追踪与免疫细胞化学、化学交感神经切除术、辣椒素处理及妊娠的影响。
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