Wilson W J, Sołtysik S S
Acta Neurobiol Exp (Wars). 1985;45(3-4):91-105.
Agonists and antagonists of dopamine, acetylcholine, and glutamate were injected bilaterally into the nucleus accumbens in 5 adult cats, and their effects on classically conditioned responses and locomotor activity were observed. Dopamine reduced conditioned consummatory responses (leg flexion and vocalization) and conditioned changes in respiration rate, but did not affect other conditioned preparatory responses (changes in heart rate and respiration amplitude). The cholinergic agonist oxotremorine reduced both conditioned and unconditioned leg flexion. The glutamatergic agonist and antagonist had no effect on any of the conditioned responses. All drugs except haloperidol increased the cats locomotor activity in an open field setting. The results suggest that dopaminergic input to the nucleus accumbens is involved in the inhibition of consummatory conditioned responses, and that the behavioral effect of dopamine in the nucleus accumbens might be dependent on the emotional state of the animal.
向5只成年猫的伏隔核双侧注射多巴胺、乙酰胆碱和谷氨酸的激动剂与拮抗剂，并观察它们对经典条件反射反应和运动活动的影响。多巴胺减少了条件性的 consummatory 反应（腿部弯曲和发声）以及呼吸频率的条件性变化，但不影响其他条件性准备反应（心率和呼吸幅度的变化）。胆碱能激动剂氧化震颤素减少了条件性和非条件性腿部弯曲。谷氨酸能激动剂和拮抗剂对任何条件反应均无影响。除氟哌啶醇外，所有药物均增加了猫在旷场环境中的运动活动。结果表明，伏隔核的多巴胺能输入参与了对 consummatory 条件反应的抑制，并且伏隔核中多巴胺的行为效应可能取决于动物的情绪状态。
