Modesto Dos Santos J L, González Recio P, Terry López O A, Leturia Frade I, Aguiar Losada B, Elejalde Guerra J I
Servicio de Medicina Interna, Complejo Hospitalario de Navarra.
An Sist Sanit Navar. 2017 Aug 31;40(2):291-294. doi: 10.23938/ASSN.0021.
Olmesartan is an angiotensin II type 1 receptor blocker commonly used in the treatment of hypertension. Several cases of sprue-like enteropathy associated with the use of this drug have been described which, even with important signs and limitations for the patient, present a full recovery after discontinuing the use of olmesartan. The case of a 64 year-old patient is presented, diagnosed with hypertension, under treatment with olmesartan-amlodipine, with chronic diarrhoea and villous atrophy on intestinal biopsies without diagnostic criteria for celiac disease and with complete remission after suspending discontinuing the use of olmesartan. Based on the clinical features presented by the case reported, the clinical and anatomopathological findings are described as well as the evolution of drug-induced enteropathy.
奥美沙坦是一种常用于治疗高血压的血管紧张素II 1型受体阻滞剂。已有数例与使用该药物相关的类口炎性腹泻病例被描述，这些病例即使给患者带来了严重症状和限制，但在停用奥美沙坦后仍能完全康复。本文介绍了一例64岁患者的病例，该患者被诊断为高血压，正在接受奥美沙坦 - 氨氯地平治疗，出现慢性腹泻，肠道活检显示绒毛萎缩，但不符合乳糜泻的诊断标准，在停用奥美沙坦后完全缓解。基于所报告病例呈现的临床特征，描述了临床及解剖病理学发现以及药物性肠病的演变过程。
