Rommel K-P, Schneider E, Witschel I, Halm U, Zachäus M
Universitätsklinik für Kardiologie - HELIOS Stiftungsprofessur, Herzzentrum Leipzig, Strümpellstr. 39, 04289, Leipzig, Deutschland.
Praxis für Pathologie Dres. Schneider/Schmidt, Leipzig, Deutschland.
Internist (Berl). 2018 Sep;59(9):961-966. doi: 10.1007/s00108-018-0417-2.
We report three cases of severe olmesartan-associated chronic diarrhea with weight loss and malassimilation syndrome. Histologically, a sprue-like enteropathy was diagnosed in each case, while serological tests for celiac disease were negative. After stopping the medication, symptoms improved within a few days. Histologically, remission was documented after 3 months. Olmesartan-associated enteropathy is an underestimated entity and an important differential diagnosis in patients with chronic diarrhea.
我们报告了三例与奥美沙坦相关的严重慢性腹泻病例，伴有体重减轻和吸收不良综合征。组织学检查显示，每例均诊断为口炎性腹泻样小肠病，而乳糜泻的血清学检测为阴性。停药后，症状在数天内改善。组织学检查显示，3个月后病情缓解。奥美沙坦相关小肠病是一个被低估的疾病实体，是慢性腹泻患者重要的鉴别诊断。
