Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, UK.
HLA. 2017 Sep;90(3):165-170. doi: 10.1111/tan.13077. Epub 2017 Jul 5.
Major histocompatibility complex (MHC) genes in mammals include highly polymorphic class I and class II genes that are critical for donor-recipient matching for transplantation. Dogs have served as an effective, directly translatable model for stem/progenitor cell transplantation. Previous analyses of MHC class I genes in dogs point to a single highly polymorphic gene, dog leukocyte antigen (DLA)-88, as an important factor in the success or failure of hematopoietic stem cell transplants. Fifty-nine DLA-88 alleles have been identified and reported so far. Here, we extend this list by presenting 13 novel DLA-88 alleles found in domestic dogs.
哺乳动物的主要组织相容性复合体 (MHC) 基因包括高度多态的 I 类和 II 类基因，这些基因对于移植的供体-受体匹配至关重要。狗已成为干细胞/祖细胞移植的有效、可直接转化的模型。先前对狗的 MHC I 类基因的分析表明，单一高度多态的基因，即犬白细胞抗原 (DLA)-88，是造血干细胞移植成功或失败的重要因素。迄今为止，已经确定并报道了 59 个 DLA-88 等位基因。在这里，我们通过展示在家犬中发现的 13 个新的 DLA-88 等位基因来扩展这个列表。
