1Department of Otolaryngology and Communicative Sciences, University of Mississippi Medical Center, Jackson, Mississippi, USA; 2School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, Texas, USA; and 3Department of Hearing and Speech Sciences, Vanderbilt University, Nashville, Tennessee.
Ear Hear. 2017 Nov/Dec;38(6):724-735. doi: 10.1097/AUD.0000000000000457.
The purpose of this study was to examine the relationship between noise exposure history, type 1 diabetes mellitus (DM), and suprathreshold measures of auditory function.
A cross-sectional study was conducted; 20 normal-hearing participants without type 1 DM were matched on age and sex to 20 normal-hearing participants with type 1 DM (n=40). Participants, all having normal audiometric thresholds, completed noise history questionnaires and a battery of auditory physiological tests including transient evoked otoacoustic emissions, distortion product otoacoustic emissions, and auditory brainstem responses (ABR) at 80 dB nHL and at 2 different stimulus rates in both ears. Amplitude and latency for waves I and V are presented. Statistical analysis included analysis of variance and multivariate linear regression.
No statistically significant difference for noise exposure history, otoacoustic emissions (OAE), or ABR findings were found between type 1 DM and matched controls. Males and females showed statistically significant differences for OAE amplitudes and ABR amplitude and latencies. However, no statistically significant relationship was found between noise outcomes and OAE or ABR findings.
No statistically significant relationship between noise history and our suprathreshold ABR or OAE findings was indicated for individuals with type 1 DM or matched controls. The lack of evidence of noise related neuropathology might be due to inadequate noise exposure or lack of comorbidities in our DM group. Implications of these findings are discussed.
本研究旨在探讨噪声暴露史、1 型糖尿病（DM）与阈上听觉功能测量值之间的关系。
本研究采用横断面研究方法，将 20 名无 1 型 DM 的听力正常者与 20 名听力正常的 1 型 DM 患者（n=40）按年龄和性别匹配。所有参与者的听阈均正常，完成噪声暴露史问卷和一系列听觉生理测试，包括瞬态诱发耳声发射、畸变产物耳声发射和在 80dB nHL 及双耳 2 种不同刺激率下的听觉脑干反应（ABR）。呈现 I 波和 V 波的幅度和潜伏期。统计分析包括方差分析和多元线性回归。
1 型 DM 患者与匹配对照组之间的噪声暴露史、耳声发射（OAE）或 ABR 结果无统计学差异。男性和女性的 OAE 幅度和 ABR 幅度和潜伏期存在统计学差异。然而，噪声结果与 OAE 或 ABR 结果之间未发现统计学显著关系。
对于 1 型 DM 患者或匹配对照组，噪声史与我们的阈上 ABR 或 OAE 结果之间无统计学显著关系。这些发现可能是由于 DM 组的噪声暴露不足或合并症缺乏，导致缺乏与噪声相关的神经病理学证据。讨论了这些发现的意义。
