Yaseen Ragheda, Branitzki-Heinemann Katja, Moubasher Hani, Setzer William N, Naim Hassan Y, von Köckritz-Blickwede Maren
Department of Physiological Chemistry, University of Veterinary Medicine Hannover, Bünteweg 17, 30559 Hannover, Germany.
Botany & Microbiology Department, Cairo University, Giza 12613, Egypt.
Biomedicines. 2017 Jul 5;5(3):40. doi: 10.3390/biomedicines5030040.
The increasing occurrence of antibiotic-resistant (.) tremendously limits the antibiotic-based treatment options; therefore, an open discussion of alternative treatment strategies is urgently needed. The use of naturally derived materials might become a more promising concept, not only as directly acting antimicrobials, but also for stimulation of the immune system. Costa Rican plant extracts were screened for their ability to enhance the antimicrobial activity of human blood-derived cells against infections. We identified three plant extracts which significantly reduced the growth of in the presence of human blood without directly acting as antibacterials: acetone bark extract, acetone vine extract and acetone bark extract (VEOEBA). The effect of VEOEBA was studied in more detail, and revealed that VEOEBA increases the antimicrobial activity of neutrophils by enhancing the formation of neutrophil extracellular traps.
抗生素耐药性的日益增加极大地限制了基于抗生素的治疗选择；因此，迫切需要对替代治疗策略进行公开讨论。使用天然来源的材料可能会成为一个更有前景的概念，不仅作为直接作用的抗菌剂，还用于刺激免疫系统。对哥斯达黎加植物提取物进行了筛选，以评估其增强人血来源细胞抗感染抗菌活性的能力。我们鉴定出三种植物提取物，它们在存在人血的情况下显著降低了[细菌名称]的生长，且并非直接作为抗菌剂：[植物名称1]丙酮树皮提取物、[植物名称2]丙酮藤提取物和[植物名称3]丙酮树皮提取物（VEOEBA）。对VEOEBA的作用进行了更详细的研究，结果表明VEOEBA通过增强中性粒细胞胞外陷阱的形成来提高中性粒细胞的抗菌活性。 （注：原文中部分植物名称、细菌名称未给出具体信息，用[植物名称]、[细菌名称]代替）
