Gierlikowska Barbara, Stachura Albert, Gierlikowski Wojciech, Demkow Urszula
Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, Warsaw, Poland.
Department of Methodology, Centre for Preclinical Research, Medical University of Warsaw, Warsaw, Poland.
Front Pharmacol. 2021 May 4;12:666732. doi: 10.3389/fphar.2021.666732. eCollection 2021.
Neutrophils are crucial elements of innate immune system, which assure host defense via a range of effector functions, such as phagocytosis, degranulation, and NET formation. The latest literature clearly indicates that modulation of effector functions of neutrophils may affect the treatment efficacy. Pharmacological modulation may affect molecular mechanisms activating or suppressing phagocytosis, degranulation or NET formation. In this review, we describe the role of neutrophils in physiology and in the course of bacterial and viral infections, illustrating the versatility and plasticity of those cells. This review also focus on the action of plant extracts, plant-derived compounds and synthetic drugs on effector functions of neutrophils. These recent advances in the knowledge can help to devise novel therapeutic approaches via pharmacological modulation of the described processes.
中性粒细胞是先天免疫系统的关键组成部分，通过一系列效应功能确保宿主防御，如吞噬作用、脱颗粒和中性粒细胞胞外陷阱形成。最新文献清楚地表明，调节中性粒细胞的效应功能可能会影响治疗效果。药理学调节可能会影响激活或抑制吞噬作用、脱颗粒或中性粒细胞胞外陷阱形成的分子机制。在本综述中，我们描述了中性粒细胞在生理以及细菌和病毒感染过程中的作用，阐明了这些细胞的多功能性和可塑性。本综述还关注植物提取物、植物源化合物和合成药物对中性粒细胞效应功能的作用。这些知识的最新进展有助于通过对所述过程的药理学调节设计新的治疗方法。
