Liu Tao, Tian Jun, Gao Wen-Chao, Chang Hong-Hong, Liu Qiang, Li Xing, Wei Wen-Long
College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Taiyuan 030024, P. R. China.
Org Biomol Chem. 2017 Jul 19;15(28):5983-5992. doi: 10.1039/c7ob01225j.
An acid-catalyzed intermolecular sulfenoamination reaction of alkenes is developed with sulfonamides as the nitrogen source and N-sulfanylsuccinimides as the sulfur source. This methodology provides a straightforward and general way to synthesize various β-sulfonylamino sulfides with high regio- and diastereoselectivity. The developed method was coupled with intramolecular C-N coupling in a one-pot procedure to afford a series of dihydrobenzothiazine derivatives, a kind of important heterocycle used as biologically active compounds in medicinal chemistry.
以磺酰胺为氮源、N-硫代琥珀酰亚胺为硫源，开发了一种酸催化的烯烃分子间硫氨基化反应。该方法提供了一种直接且通用的方法，可高区域选择性和非对映选择性地合成各种β-磺酰基氨基硫醚。所开发的方法与分子内C-N偶联在一锅法中相结合，以得到一系列二氢苯并噻嗪衍生物，这是一类重要的杂环化合物，在药物化学中用作生物活性化合物。
