Chen Wei, Wang Wanxiang, Wu Run, Zhou Haiping, Yu Pingbing
Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, 610031, China .
Chem Asian J. 2024 Dec 2;19(23):e202400945. doi: 10.1002/asia.202400945. Epub 2024 Oct 28.
A convenient and practical multicomponent strategy for the sulfenoamination of alkenes was realized, which using free-thiols as the sulfur-reagent, NIS both as radical initiator and an N-nucleophile. This protocol excellent in terms of transition-metal-free, good functional group tolerance, easily available substrates and facile scale-up. And provided a direct- and general way to synthesize various β-succinimide sulfides with high regioselectivity.
实现了一种方便实用的烯烃硫胺化多组分策略，该策略使用游离硫醇作为硫试剂，NIS既作为自由基引发剂又作为N-亲核试剂。该方案在无过渡金属、良好的官能团耐受性、易于获得的底物和易于放大方面表现出色。并且提供了一种直接且通用的方法来高区域选择性地合成各种β-琥珀酰亚胺硫化物。
