硫代咪唑与烯烃的分子间区域和立体选择性亚磺酰胺化反应。
Intermolecular Regio- and Stereoselective Sulfenoamination of Alkenes with Thioimidazoles.
机构信息
Department of Chemistry and Biochemistry, School of Green Chemistry and Engineering, The University of Toledo , 2801 West Bancroft Street, Toledo, Ohio 43606, United States.
出版信息
Org Lett. 2017 Nov 17;19(22):6204-6207. doi: 10.1021/acs.orglett.7b03128. Epub 2017 Oct 27.
An intermolecular sulfenoamination reaction utilizing a stable sulfur precursor with a broad range of alkene structures is described. More importantly, these reactions proceed in a highly regio- and stereoselective manner to afford interesting heterocyclic motifs ready for biological studies. In addition, a highly regiodivergent approach to access the opposite regioisomers for styrene derivatives was also developed.
本文描述了一种利用稳定的硫前体制备的分子间亚磺酰胺化反应，该反应适用于多种烯烃结构。更重要的是，这些反应具有高度的区域和立体选择性，能够得到适合生物研究的有趣杂环结构。此外，还开发了一种高度区域发散的方法，用于制备相反区域异构体的苯乙烯衍生物。
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