镍催化芳基 2-吡啶基醚的碳氧键断裂胺化反应。
Nickel-Catalyzed Amination of Aryl 2-Pyridyl Ethers via Cleavage of the Carbon-Oxygen Bond.
机构信息
CAS Key Laboratory of Soft Matter Chemistry, Hefei National Laboratory for Physical Sciences at Microscale and Department of Chemistry, University of Science and Technology of China , Hefei, Anhui 230026, People's Republic of China.
Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) , Tianjin 300072, People's Republic of China.
出版信息
Org Lett. 2017 Jul 21;19(14):3723-3726. doi: 10.1021/acs.orglett.7b01549. Epub 2017 Jul 5.
Reaction of aryl 2-pyridyl ethers with amines was carried out via Ni-catalyzed C-O bond cleavage, giving aniline derivatives in reasonable to excellent yields. Both electron-rich and electron-poor aryl 2-pyridyl ethers and a wide range of amines can be used in the transformation. The method provides a conversion way for the 2-pyridyloxy directing group in the C-H bond functionalization reactions.
芳基 2-吡啶基醚与胺的反应通过 Ni 催化的 C-O 键断裂进行，以合理至优异的收率得到苯胺衍生物。富电子和缺电子的芳基 2-吡啶基醚以及广泛的胺都可以在转化中使用。该方法为 C-H 键功能化反应中 2-吡啶氧基导向基团提供了一种转化方式。
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