铁催化芳基醚的 C-O 键断裂硼化反应。
Iron-Catalyzed Borylation of Aryl Ethers via Cleavage of C-O Bonds.
机构信息
School of Pharmaceutical Sciences, Chongqing University, Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing 401331, P. R. China.
School of Preclinical Medicine, North Sichuan Medical College, Sichuan Key Laboratory of Medical Imaging & Department of Chemistry, Nanchong, Sichuan 637000, China.
出版信息
Org Lett. 2020 Apr 17;22(8):2950-2955. doi: 10.1021/acs.orglett.0c00679. Epub 2020 Apr 1.
Herein, we report the iron-catalyzed borylation of aryl ethers and aryl amines via cleavage of C-O and C-N bonds. This protocol does not require the use of Grignard reagents and displays a broad substrate scope, which allows the late-stage borylation. It also provides facile access to multisubstituted arenes through C-H functionalization using 2-pyridyloxy as the directing group.
在此，我们报告了通过 C-O 和 C-N 键断裂实现的铁催化芳基醚和芳胺的硼化反应。该方案不需要使用格氏试剂，并具有广泛的底物范围，允许进行后期硼化反应。此外，该方案还通过使用 2-吡啶氧基作为导向基团，通过 C-H 官能化反应，为多取代芳烃提供了简便的合成途径。
Zotero 插件