Aronsson Linus, Andersson Roland, Swahn Fredrik, Ansari Daniel
a Department of Clinical Sciences Lund , Lund University, Skane University Hospital , Lund , Sweden Surgery.
Scand J Gastroenterol. 2017 Oct;52(10):1049-1051. doi: 10.1080/00365521.2017.1349175. Epub 2017 Jul 5.
Pancreatic cystic lesions represent a heterogeneous group of diseases ranging from benign to malignant lesions. They are increasingly being detected due to the widespread use of cross-sectional imaging. Their management is a challenge because it is often not possible to reliably discriminate between malignant and nonmalignant lesions using current imaging technology. Next-generation sequencing (NGS) has the ability of both whole genome and targeted sequencing at a low cost and from a limited amount of DNA. NGS of cyst fluid aspired by endoscopic ultrasonography-guided fine-needle aspiration provides a valuable tool in biomarker research and may in the future help improve diagnosis and management of pancreatic cystic lesions.
胰腺囊性病变是一组异质性疾病，范围从良性病变到恶性病变。由于横断面成像的广泛应用，它们越来越多地被检测出来。其管理是一项挑战，因为使用当前的成像技术往往无法可靠地区分恶性和非恶性病变。新一代测序（NGS）能够以低成本对有限量的DNA进行全基因组和靶向测序。通过内镜超声引导下细针穿刺抽吸的囊液进行NGS，为生物标志物研究提供了一种有价值的工具，未来可能有助于改善胰腺囊性病变的诊断和管理。
