Barbosa-Lorenzo Raquel, Ruano-Ravina Alberto, Cerdeira-Caramés Sara, Raíces-Aldrey Mónica, Barros-Dios Juan M
Facultad de Medicina, Universidad de Santiago de Compostela, Santiago de Compostela, España.
Hospital Comarcal de Monforte de Lemos, Monforte de Lemos, España.
Cad Saude Publica. 2017 Jul 3;33(6):e00189415. doi: 10.1590/0102-311X00189415.
Case-control studies show an association between residential radon and lung cancer. The aim of this paper is to investigate this association through a cohort study. We designed an ambispective cohort study using the Galician radon map, Spain, with controls drawn from a previous case-control study. Subjects were recruited between 2002 and 2009. The data were cross-checked to ascertain lung cancer incidence and then analysed using a Cox regression model. A total of 2,127 subjects participated; 24 lung cancer cases were identified; 76.6% of subjects were drawn from the radon map. The adjusted hazard ratio was 1.2 (95%CI: 0.5-2.8) for the category of subjects exposed to 50Bq/m3 or more. This risk rose when subjects from the case-control study were analyzed separately. In conclusion, we did not observe any statistically significant association between residential radon exposure and lung cancer; however, it appears that with a sample of greater median age (such as participants from the case-control study), the risk of lung cancer would have been higher.
病例对照研究表明，室内氡气与肺癌之间存在关联。本文旨在通过队列研究来调查这种关联。我们利用西班牙加利西亚的氡气地图设计了一项回顾性队列研究，对照组取自先前的一项病例对照研究。研究对象于2002年至2009年招募。对数据进行交叉核对以确定肺癌发病率，然后使用Cox回归模型进行分析。共有2127名研究对象参与；确诊24例肺癌病例；76.6%的研究对象来自氡气地图。对于暴露于50Bq/m3及以上的研究对象类别，调整后的风险比为1.2（95%置信区间：0.5 - 2.8）。当分别分析病例对照研究中的研究对象时，这种风险有所上升。总之，我们未观察到室内氡气暴露与肺癌之间存在任何统计学上的显著关联；然而，似乎对于年龄中位数更大的样本（如病例对照研究中的参与者），患肺癌的风险会更高。
