犬猫原发性肺肿瘤与环境氡活度的生态水平分析
Ecological level analysis of primary lung tumors in dogs and cats and environmental radon activity.
作者信息
Fowler Brittany L, Johannes Chad M, O'Connor Annette, Collins Deanna, Lustgarten Jonathan, Yuan Chaohui, Weishaar Kristen, Sullivan Kelly, Hume Kelly R, Mahoney Jennifer, Vale Brittany, Schubert Alicia, Ball Valerie, Cooley-Lock Katie, Curran Kaitlin M, Nafe Laura, Gedney Allison, Weatherford Megan, LeVine Dana N
机构信息
Iowa State University College of Veterinary Medicine, Ames, Iowa, USA.
Compassion First Pets Red Bank Veterinary Hospital, Tinton Falls, New Jersey, USA.
出版信息
J Vet Intern Med. 2020 Nov;34(6):2660-2670. doi: 10.1111/jvim.15936. Epub 2020 Nov 3.
BACKGROUND
Epidemiologic studies suggest residential radon exposure might increase the risk of primary lung cancer in people, but these studies are limited by subject mobility. This limitation might be overcome by evaluating the association in pets.
HYPOTHESIS
Primary pulmonary neoplasia (PPN) rate is higher in dogs and cats residing in counties with a high radon exposure risk (Environmental Protection Agency [EPA] zone 1) compared to zones 2 (moderate radon exposure risk) and 3 (low radon exposure risk).
ANIMALS
Six hundred ninety client-owned dogs and 205 client-owned cats with PPN.
METHODS
Retrospective review of medical records at 10 veterinary colleges identified dogs and cats diagnosed with PPN between 2010 and 2015. Each patient's radon exposure was determined by matching the patient's zip code with published county radon exposure risk. County level PPN rates were calculated using the average annual county cat and dog populations. The PPN counts per 100 000 dog/cat years at risk (PPN rates) were compared across radon zones for each species.
RESULTS
The PPN rate ratio in counties in high radon zone (1) was approximately 2-fold higher than in counties in lower radon zones for dogs (rate ratio zone 1 to 2, 2.49; 95% confidence interval [CI], 1.56-4.00; rate ratio zone 1 to 3, 2.29; 95% CI, 1.46-3.59) and cats (rate ratio zone 1 to 2, 2.13; 95% CI, 0.95-4.79; zone 1 to 3, 1.81; 95% CI, 0.9-3.61).
CONCLUSIONS AND CLINICAL IMPORTANCE
Exposure to household radon might play a role in development of PPN in dogs and cats.
背景
流行病学研究表明，居民接触氡气可能会增加人类患原发性肺癌的风险，但这些研究受到研究对象流动性的限制。通过评估宠物中的这种关联，可能会克服这一限制。
假设
与氡暴露风险中等的2区和氡暴露风险低的3区相比，居住在氡暴露风险高的县（环境保护局[EPA]1区）的犬猫原发性肺肿瘤（PPN）发生率更高。
动物
690只客户拥有的患有PPN的犬和205只客户拥有的患有PPN的猫。
方法
对10所兽医学院的病历进行回顾性研究，确定2010年至2015年间被诊断患有PPN的犬猫。通过将患者的邮政编码与已公布的县氡暴露风险相匹配，确定每只患者的氡暴露情况。使用各县猫和犬的年平均数量计算县级PPN发生率。比较每个物种在不同氡区每100,000犬/猫年的PPN计数（PPN发生率）。
结果
对于犬，高氡区（1区）各县的PPN发生率比低氡区各县高约2倍（1区与2区的发生率比为2.49；95%置信区间[CI]，1.56 - 4.00；1区与3区的发生率比为2.29；95%CI，1.46 - 3.59）；对于猫，1区与2区的发生率比为2.13；95%CI，0.95 - 4.79；1区与3区的发生率比为1.81；95%CI，0.9 - 3.61。
结论及临床意义
接触家庭氡气可能在犬猫PPN的发生中起作用。
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