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为一名有“不要复苏”医嘱的青少年使用丙泊酚进行姑息性镇静。

Palliative Sedation With Propofol for an Adolescent With a DNR Order.

作者信息

Johnson Liza-Marie, Frader Joel, Wolfe Joanne, Baker Justin N, Anghelescu Doralina L, Lantos John D

机构信息

Division of Oncology Hospitalist Medicine, St. Jude's Hospital and Research Center, Memphis, Tennessee.

Pediatric Palliative and End-of-Life Care, Ann and Robert H. Lurie Children's Hospital, Chicago, Illinois.

出版信息

Pediatrics. 2017 Aug;140(2). doi: 10.1542/peds.2017-0487. Epub 2017 Jul 5.

DOI:10.1542/peds.2017-0487
PMID:28679640
Abstract

Death from cancer is often painful. Usually, the pain can be relieved in ways that allow patients to remain awake and alert until the end. Sometimes, however, the only way to relieve pain is to sedate patients until they are unconscious. This method has been called palliative sedation therapy. Palliative sedation therapy is controversial because it can be misunderstood as euthanasia. We present a case in which an adolescent who is dying of leukemia has intractable pain. Experts in oncology, ethics, pain management, and palliative care discuss the trade-offs associated with different treatment strategies.

摘要

死于癌症通常是痛苦的。通常,疼痛可以通过让患者保持清醒和警觉直到生命结束的方式得到缓解。然而,有时缓解疼痛的唯一方法是使患者镇静直至失去意识。这种方法被称为姑息性镇静疗法。姑息性镇静疗法存在争议,因为它可能被误解为安乐死。我们呈现一个病例,一名患有白血病濒临死亡的青少年遭受着难以忍受的疼痛。肿瘤学、伦理学、疼痛管理和姑息治疗方面的专家讨论了与不同治疗策略相关的权衡。

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Palliative Sedation With Propofol for an Adolescent With a DNR Order.为一名有“不要复苏”医嘱的青少年使用丙泊酚进行姑息性镇静。
Pediatrics. 2017 Aug;140(2). doi: 10.1542/peds.2017-0487. Epub 2017 Jul 5.
2
Relieving existential suffering through palliative sedation: discussion of an uneasy practice.通过姑息性镇静缓解存在主义痛苦:对一种不安实践的探讨。
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Refractory pain, existential suffering, and palliative care: releasing an unbearable lightness of being.难治性疼痛、生存性痛苦与姑息治疗:释放难以承受的生命之轻
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Palliative Sedation Therapy in Pediatrics: An Algorithm and Clinical Practice Update.儿科姑息性镇静治疗:一种算法及临床实践更新
Children (Basel). 2022 Dec 1;9(12):1887. doi: 10.3390/children9121887.
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Palliative care for adolescents and young adults with advanced illness: A scoping review.晚期疾病青少年和年轻成人的姑息治疗:范围综述。
Palliat Med. 2023 Jan;37(1):88-107. doi: 10.1177/02692163221136160. Epub 2022 Nov 9.
3
Compassionate de-escalation of life-sustaining treatments in pediatric oncology: An opportunity for palliative care and intensive care collaboration.
儿科肿瘤学中维持生命治疗的同情性降级:姑息治疗与重症监护协作的契机。
Front Oncol. 2022 Oct 13;12:1017272. doi: 10.3389/fonc.2022.1017272. eCollection 2022.
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Dexmedetomidine and Propofol at End of Life in Pediatric Oncology: Trends in Palliative Sedation Therapy.右美托咪定和丙泊酚在儿科肿瘤终末期的应用:姑息镇静治疗趋势。
J Palliat Med. 2023 Jan;26(1):79-86. doi: 10.1089/jpm.2021.0650. Epub 2022 Aug 9.
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Palliative sedation for children at end of life: a retrospective cohort study.终末期儿童的姑息性镇静:回顾性队列研究。
BMC Palliat Care. 2022 Apr 27;21(1):57. doi: 10.1186/s12904-022-00947-y.
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General anaesthesia in end-of-life care: extending the indications for anaesthesia beyond surgery.终末期关怀中的全身麻醉:将麻醉适应证扩展到手术之外。
Anaesthesia. 2021 Oct;76(10):1308-1315. doi: 10.1111/anae.15459. Epub 2021 Apr 20.
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Bioengineering (Basel). 2018 Oct 13;5(4):85. doi: 10.3390/bioengineering5040085.
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Palliative Sedation for the Terminally Ill Patient.晚期病危患者的缓和性镇静治疗。
CNS Drugs. 2018 Oct;32(10):951-961. doi: 10.1007/s40263-018-0576-7.