• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

全耦合三维支架内再狭窄模拟与数据的比较

A Comparison of Fully-Coupled 3D In-Stent Restenosis Simulations to Data.

作者信息

Zun Pavel S, Anikina Tatiana, Svitenkov Andrew, Hoekstra Alfons G

机构信息

Saint Petersburg State University of Information Technologies, Mechanics and Optics (ITMO) UniversitySt. Petersburg, Russia.

Computational Science Lab, Faculty of Science, Institute for Informatics, University of AmsterdamAmsterdam, Netherlands.

出版信息

Front Physiol. 2017 May 23;8:284. doi: 10.3389/fphys.2017.00284. eCollection 2017.

DOI:10.3389/fphys.2017.00284
PMID:28588498
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5440556/
Abstract

We describe our fully-coupled 3D multiscale model of in-stent restenosis, with blood flow simulations coupled to smooth muscle cell proliferation, and report results of numerical simulations performed with this model. This novel model is based on several previously reported 2D models. We study the effects of various parameters on the process of restenosis and compare with porcine data where we observe good qualitative agreement. We study the effects of stent deployment depth (and related injury score), reendothelization speed, and simulate the effect of stent width. Also we demonstrate that we are now capable to simulate restenosis in real-sized (18 mm long, 2.8 mm wide) vessel geometries.

摘要

我们描述了我们用于支架内再狭窄的全耦合三维多尺度模型，该模型将血流模拟与平滑肌细胞增殖相耦合，并报告了使用此模型进行的数值模拟结果。这个新模型基于几个先前报道的二维模型。我们研究了各种参数对再狭窄过程的影响，并与猪的数据进行比较，在这些数据中我们观察到了良好的定性一致性。我们研究了支架植入深度（以及相关损伤评分）、再内皮化速度的影响，并模拟了支架宽度的影响。此外，我们证明我们现在有能力在实际尺寸（长18毫米、宽2.8毫米）的血管几何形状中模拟再狭窄。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49bc/5440556/78fa5f9c3bc6/fphys-08-00284-g0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49bc/5440556/b9ebf95fc218/fphys-08-00284-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49bc/5440556/d99962eb4ee3/fphys-08-00284-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49bc/5440556/8895ff7826f5/fphys-08-00284-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49bc/5440556/8933db83e4d1/fphys-08-00284-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49bc/5440556/6f6c1d47f89b/fphys-08-00284-g0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49bc/5440556/78fa5f9c3bc6/fphys-08-00284-g0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49bc/5440556/b9ebf95fc218/fphys-08-00284-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49bc/5440556/d99962eb4ee3/fphys-08-00284-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49bc/5440556/8895ff7826f5/fphys-08-00284-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49bc/5440556/8933db83e4d1/fphys-08-00284-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49bc/5440556/6f6c1d47f89b/fphys-08-00284-g0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49bc/5440556/78fa5f9c3bc6/fphys-08-00284-g0011.jpg

相似文献

1
A Comparison of Fully-Coupled 3D In-Stent Restenosis Simulations to Data.全耦合三维支架内再狭窄模拟与数据的比较
Front Physiol. 2017 May 23;8:284. doi: 10.3389/fphys.2017.00284. eCollection 2017.
2
Multi-scale simulations of the dynamics of in-stent restenosis: impact of stent deployment and design.多尺度模拟支架内再狭窄动力学：支架部署和设计的影响。
Interface Focus. 2011 Jun 6;1(3):365-73. doi: 10.1098/rsfs.2010.0024. Epub 2011 Mar 30.
3
An agent-based model of the response to angioplasty and bare-metal stent deployment in an atherosclerotic blood vessel.一种基于代理的动脉粥样硬化血管中血管成形术和裸金属支架植入反应模型。
PLoS One. 2014 Apr 14;9(4):e94411. doi: 10.1371/journal.pone.0094411. eCollection 2014.
4
5
Effects of local coronary blood flow dynamics on the predictions of a model of in-stent restenosis.局部冠状动脉血流动力学对支架内再狭窄模型预测的影响。
J Biomech. 2021 May 7;120:110361. doi: 10.1016/j.jbiomech.2021.110361. Epub 2021 Mar 6.
6
Time-dependent 3D simulations of the hemodynamics in a stented coronary artery.冠状动脉支架植入后血流动力学的时间依赖性三维模拟
Biomed Mater. 2007 Mar;2(1):S28-37. doi: 10.1088/1748-6041/2/1/S05. Epub 2007 Mar 2.
7
Preventive effects of the heparin-coated stent on restenosis in the porcine model.肝素涂层支架对猪模型再狭窄的预防作用。
Catheter Cardiovasc Interv. 1999 Nov;48(3):324-30. doi: 10.1002/(sici)1522-726x(199911)48:3<324::aid-ccd20>3.0.co;2-k.
8
Determination of the influence of stent strut thickness using the finite element method: implications for vascular injury and in-stent restenosis.使用有限元方法确定支架支柱厚度的影响：对血管损伤和支架内再狭窄的意义。
Med Biol Eng Comput. 2009 Apr;47(4):385-93. doi: 10.1007/s11517-009-0432-5. Epub 2009 Feb 3.
9
The adipokine vaspin is associated with decreased coronary in-stent restenosis in vivo and inhibits migration of human coronary smooth muscle cells in vitro.脂联素 vaspin 与体内冠状动脉支架内再狭窄减少有关，并抑制体外人冠状动脉平滑肌细胞的迁移。
PLoS One. 2020 May 11;15(5):e0232483. doi: 10.1371/journal.pone.0232483. eCollection 2020.
10
Uncertainty quantification of a three-dimensional in-stent restenosis model with surrogate modelling.基于代理模型的三维支架内再狭窄模型的不确定性量化。
J R Soc Interface. 2022 Feb;19(187):20210864. doi: 10.1098/rsif.2021.0864. Epub 2022 Feb 23.

引用本文的文献

1
Impact of Tissue Damage and Hemodynamics on Restenosis Following Percutaneous Transluminal Angioplasty: A Patient-Specific Multiscale Model.经皮腔内血管成形术后组织损伤和血液动力学对再狭窄的影响：基于患者的多尺度模型。
Ann Biomed Eng. 2024 Aug;52(8):2203-2220. doi: 10.1007/s10439-024-03520-1. Epub 2024 May 3.
2
A predictive multiscale model of in-stent restenosis in femoral arteries: linking haemodynamics and gene expression with an agent-based model of cellular dynamics.一种预测性的股动脉支架内再狭窄多尺度模型：将血液动力学和基因表达与基于代理的细胞动力学模型联系起来。
J R Soc Interface. 2022 Mar;19(188):20210871. doi: 10.1098/rsif.2021.0871. Epub 2022 Mar 30.
3

本文引用的文献

1
A cell-based mechanical model of coronary artery tunica media.一种基于细胞的冠状动脉中膜力学模型。
J R Soc Interface. 2017 Jul;14(132). doi: 10.1098/rsif.2017.0028.
2
Towards the virtual artery: a multiscale model for vascular physiology at the physics-chemistry-biology interface.迈向虚拟动脉：物理-化学-生物学界面的血管生理学多尺度模型。
Philos Trans A Math Phys Eng Sci. 2016 Nov 13;374(2080). doi: 10.1098/rsta.2016.0146.
3
A discrete mesoscopic particle model of the mechanics of a multi-constituent arterial wall.一种多成分动脉壁力学的离散介观粒子模型。
Uncertainty quantification of a three-dimensional in-stent restenosis model with surrogate modelling.
基于代理模型的三维支架内再狭窄模型的不确定性量化。
J R Soc Interface. 2022 Feb;19(187):20210864. doi: 10.1098/rsif.2021.0864. Epub 2022 Feb 23.
4
Multiscale Modeling of Vascular Remodeling Induced by Wall Shear Stress.壁面剪应力诱导血管重塑的多尺度建模
Front Physiol. 2022 Jan 27;12:808999. doi: 10.3389/fphys.2021.808999. eCollection 2021.
5
Multiscale Computational Modeling of Vascular Adaptation: A Systems Biology Approach Using Agent-Based Models.血管适应性的多尺度计算建模：一种使用基于智能体模型的系统生物学方法。
Front Bioeng Biotechnol. 2021 Nov 2;9:744560. doi: 10.3389/fbioe.2021.744560. eCollection 2021.
6
Computational modeling for cardiovascular tissue engineering: the importance of including cell behavior in growth and remodeling algorithms.心血管组织工程的计算建模：在生长和重塑算法中纳入细胞行为的重要性。
Curr Opin Biomed Eng. 2020 Sep;15:1-9. doi: 10.1016/j.cobme.2019.12.007.
7
Computational model of damage-induced growth in soft biological tissues considering the mechanobiology of healing.考虑愈合的力学生物学的软生物组织损伤诱导生长的计算模型。
Biomech Model Mechanobiol. 2021 Aug;20(4):1297-1315. doi: 10.1007/s10237-021-01445-5. Epub 2021 Mar 26.
8
[Review of studies on the biomechanical modelling of the coupling effect between stent degradation and blood vessel remodeling].[支架降解与血管重塑耦合效应的生物力学建模研究综述]
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2020 Dec 25;37(6):956-966. doi: 10.7507/1001-5515.202008007.
9
Mechanistic evaluation of long-term in-stent restenosis based on models of tissue damage and growth.基于组织损伤与生长模型的长期支架内再狭窄机制评估
Biomech Model Mechanobiol. 2020 Oct;19(5):1425-1446. doi: 10.1007/s10237-019-01279-2. Epub 2020 Jan 7.
10
Detection of arterial wall abnormalities via Bayesian model selection.通过贝叶斯模型选择检测动脉壁异常。
R Soc Open Sci. 2019 Oct 16;6(10):182229. doi: 10.1098/rsos.182229. eCollection 2019 Oct.
J R Soc Interface. 2016 Jan;13(114):20150964. doi: 10.1098/rsif.2015.0964.
4
Management of drug eluting stent in-stent restenosis: A systematic review and meta-analysis.药物洗脱支架内再狭窄的管理：一项系统评价和荟萃分析。
Catheter Cardiovasc Interv. 2016 May;87(6):1080-91. doi: 10.1002/ccd.26151. Epub 2015 Nov 28.
5
Treatment strategies for coronary in-stent restenosis: systematic review and hierarchical Bayesian network meta-analysis of 24 randomised trials and 4880 patients.冠状动脉支架内再狭窄的治疗策略：对24项随机试验和4880例患者的系统评价与分层贝叶斯网络荟萃分析
BMJ. 2015 Nov 4;351:h5392. doi: 10.1136/bmj.h5392.
6
Computational modelling of atherosclerosis.动脉粥样硬化的计算建模
Brief Bioinform. 2016 Jul;17(4):562-75. doi: 10.1093/bib/bbv081. Epub 2015 Sep 22.
7
Role of Animal Models in Coronary Stenting.动物模型在冠状动脉支架置入术中的作用。
Ann Biomed Eng. 2016 Feb;44(2):453-65. doi: 10.1007/s10439-015-1414-4. Epub 2015 Aug 11.
8
An in silico study on the role of smooth muscle cell migration in neointimal formation after coronary stenting.一项关于平滑肌细胞迁移在冠状动脉支架置入术后新生内膜形成中作用的计算机模拟研究。
J R Soc Interface. 2015 Jul 6;12(108):20150358. doi: 10.1098/rsif.2015.0358.
9
A robust anisotropic hyperelastic formulation for the modelling of soft tissue.一种用于软组织建模的稳健各向异性超弹性公式。
J Mech Behav Biomed Mater. 2014 Nov;39:48-60. doi: 10.1016/j.jmbbm.2014.06.016. Epub 2014 Jul 11.
10
From histology and imaging data to models for in-stent restenosis.从组织学和成像数据到支架内再狭窄模型。
Int J Artif Organs. 2014 Oct;37(10):786-800. doi: 10.5301/ijao.5000336. Epub 2014 Jul 4.