Çetin Gözde, Utku Uygar, Atilla Nurhan, Gişi Kadir, Sayarlioğlu Mehmet
Department of Internal Diseases, Division of Rheumatology, Kahramanmaraş Sütçü İmam University School of Medicine, Kahramanmaraş, Turkey.
Department of Neurology, Kahramanmaraş Sütçü İmam University School of Medicine, Kahramanmaraş, Turkey.
Noro Psikiyatr Ars. 2017 Jun;54(2):105-107. doi: 10.5152/npa.2016.12396. Epub 2016 Dec 8.
It is known that there is a relationship between systemic inflammation and atherosclerosis. Atherosclerosis is one of the best-known causes of cerebrovascular diseases. The aim of this study was to assess cerebral blood flow velocity using transcranial Doppler (TCD) ultrasonography in patients with familial Mediterranean fever (FMF).
A total of 30 patients aged from 20 to 50 years with FMF were enrolled in the FMF group consecutively. The control group (non-FMF group) consisted of 30 age- and sex-matched randomly selected patients without FMF who had other diagnoses such as fibromyalgia and did not have risk factors for atherosclerosis. Bilateral peak-systolic, end-diastolic, and mean blood flow velocities in the middle cerebral artery (MCA), values of Gosling's pulsatility index, and values of Pourcelot's resistance index were recorded using TCD ultrasonography by a neurosonologist blinded to the FMF and control groups.
There were 30 participants in the FMF group in remission (male/female: 4/26, mean age: 34.7±5.9 years) and 30 participants in the control group (male/female: 4/26, mean age: 32.3±4.7 years). C-reactive protein levels and bilateral blood flow velocities in the MCA were significantly higher in the FMF group than in the control group.
This study suggests that persistent clinical and subclinical inflammation in patients with FMF causes an increase in cerebral blood flow velocities. Our findings provide an insight into this association between FMF and cerebrovascular diseases.
已知全身炎症与动脉粥样硬化之间存在关联。动脉粥样硬化是最广为人知的脑血管疾病病因之一。本研究的目的是使用经颅多普勒（TCD）超声检查评估家族性地中海热（FMF）患者的脑血流速度。
连续纳入30例年龄在20至50岁之间的FMF患者作为FMF组。对照组（非FMF组）由30例年龄和性别匹配的随机选择的无FMF患者组成，这些患者有其他诊断，如纤维肌痛，且无动脉粥样硬化危险因素。由一位对FMF组和对照组情况不知情的神经超声医师使用TCD超声记录大脑中动脉（MCA）的双侧收缩期峰值、舒张末期和平均血流速度、戈斯林搏动指数值以及普尔塞洛阻力指数值。
FMF组有30例处于缓解期的参与者（男/女：4/26，平均年龄：34.7±5.9岁），对照组有30例参与者（男/女：4/26，平均年龄：32.3±4.7岁）。FMF组的C反应蛋白水平和MCA双侧血流速度显著高于对照组。
本研究表明，FMF患者持续的临床和亚临床炎症导致脑血流速度增加。我们的研究结果为FMF与脑血管疾病之间的这种关联提供了见解。
