Sürer Adanir Aslı, Gizli Çoban Özge, Özatalay Esin
Department of Child and Adolescent Psychiatry, Akdeniz University School of Medicine, Antalya, Turkey.
Noro Psikiyatr Ars. 2017 Jun;54(2):187-188. doi: 10.5152/npa.2017.18062. Epub 2017 Jun 1.
Autistic spectrum disorder is a neurodevelopmental disorder characterized by qualitative impairment in social interactions and communication skills. In addition to these core features, sensory processing abnormalities such as auditory hypersensitivity have been frequently reported. Although the cause of auditory hypersensitivity remains unknown, it is thought to be associated with decreased inhibitory processing, possibly resulting from an abnormal sensory gating system or dysfunction of inhibitory interneurons. Its relation to drugs has not been well documented to date. In the literature, there is only one case on hyperacusis that worsened with risperidone in a 5-year-old girl with autism. Here we represent the case of an 11-year-old boy with autism, in whom hyperacusis worsened with risperidone, decreased after the discontinuation of the medication, and re-occurred after the prescription of the drug again. Although auditory hypersensitivity tends to affect the child's daily life negatively and is found to be correlated with behavioral problems in autistic patients, we still know very little about its etiology, treatment, and conditions related to it. There is a great need for conducting further studies in this regard.
自闭症谱系障碍是一种神经发育障碍，其特征是社交互动和沟通技能存在质性损害。除了这些核心特征外，诸如听觉过敏等感觉处理异常也经常被报道。尽管听觉过敏的原因尚不清楚，但据认为与抑制性处理能力下降有关，这可能是由异常的感觉门控系统或抑制性中间神经元功能障碍导致的。迄今为止，其与药物的关系尚未得到充分记录。在文献中，仅有一例5岁自闭症女孩使用利培酮后听觉过敏加重的病例。在此，我们报告一例11岁自闭症男孩的病例，该男孩使用利培酮后听觉过敏加重，停药后减轻，再次用药后又复发。尽管听觉过敏往往会对儿童的日常生活产生负面影响，并且被发现与自闭症患者的行为问题相关，但我们对其病因、治疗及相关情况仍知之甚少。在这方面非常需要进行进一步的研究。
