贝尔麻痹患者的氧化应激与抗氧化状态
Oxidative Stress and Antioxidant Status in Patients with Bell's Palsy.
作者信息
Terzi Suat, Dursun Engin, Yılmaz Adnan, Özergin Coşkun Zerrin, Özgür Abdulkadir, Çeliker Metin, Demirci Münir
机构信息
Recep Tayyip Erdogan University, Medical Faculty, Department of Otorhinolaryngology, Rize, Turkey.
Recep Tayyip Erdogan University, Medical Faculty, Department of Biochemistry, Rize, Turkey.
出版信息
J Med Biochem. 2017 Jan 25;36(1):18-22. doi: 10.1515/jomb-2016-0033. eCollection 2017 Jan.
BACKGROUND
Bell's palsy (BP) is the most common acute mononeuropathy of unilateral facial paralysis. Immune, infective and ischaemic mechanisms are potential contributors to the development of BP, but the precise cause remains unclear. Recently, oxidative stress has been proposed as a risk factor of various idiopathic diseases. The aim of this study was to investigate the possible role of oxidative stress in patients with BP.
METHODS
Thirty-two patients with BP and 30 healthy controls were included in this study. Serum total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) were measured by the Erel method.
RESULTS
Serum TOS activities and OSI values were significantly higher in patients with BP compared with the control group (P <0.003 for all comparisons), whereas there was no significant difference between the groups in terms of TAS levels (P >0.05).
CONCLUSIONS
The data suggest that oxidative stress is increased in BP. These results of high oxidative stress in patients with BP may be helpful to clarify the etiopathogenesis of BP and contribute to improvement in the management or prevention of the disease.
背景
贝尔麻痹（BP）是单侧面部麻痹最常见的急性单神经病。免疫、感染和缺血机制可能是BP发病的原因，但确切病因仍不清楚。最近，氧化应激被认为是各种特发性疾病的危险因素。本研究旨在探讨氧化应激在BP患者中的可能作用。
方法
本研究纳入了32例BP患者和30例健康对照。采用Erel法测定血清总氧化状态（TOS）、总抗氧化状态（TAS）和氧化应激指数（OSI）。
结果
与对照组相比，BP患者血清TOS活性和OSI值显著升高（所有比较P<0.003），而两组间TAS水平无显著差异（P>0.05）。
结论
数据表明BP患者氧化应激增加。BP患者氧化应激升高的这些结果可能有助于阐明BP的发病机制，并有助于改善该疾病的管理或预防。
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