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Comparison of the uptake of untargeted and targeted immunostimulatory nanoparticles by immune cells in the microenvironment of metastatic breast cancer.转移性乳腺癌微环境中免疫细胞对非靶向和靶向免疫刺激纳米颗粒摄取的比较。
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Epithelial-Mesenchymal Transition Programs and Cancer Stem Cell Phenotypes: Mediators of Breast Cancer Therapy Resistance.上皮-间充质转化程序和癌症干细胞表型：乳腺癌治疗耐药性的介导者。
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Regulating cellular cyclic adenosine monophosphate: "Sources," "sinks," and now, "tunable valves".调节细胞环腺苷酸：“来源”、“汇”，以及现在的“可调阀”。
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本文引用的文献

1
Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability.蛋白激酶A的激活会导致间充质向上皮转化以及肿瘤起始能力的丧失。
Science. 2016 Mar 4;351(6277):aad3680. doi: 10.1126/science.aad3680.
2
Metastatic colonization by circulating tumour cells.循环肿瘤细胞的转移定植
Nature. 2016 Jan 21;529(7586):298-306. doi: 10.1038/nature17038.
3
Design of Next-Generation G Protein-Coupled Receptor Drugs: Linking Novel Pharmacology and In Vivo Animal Models.下一代 G 蛋白偶联受体药物的设计：新型药理学与体内动物模型的关联。
Annu Rev Pharmacol Toxicol. 2016;56:535-59. doi: 10.1146/annurev-pharmtox-011613-140012.
4
Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance.上皮-间质转化并非肺转移所必需，但会导致化疗耐药。
Nature. 2015 Nov 26;527(7579):472-6. doi: 10.1038/nature15748. Epub 2015 Nov 11.
5
Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer.上皮-间质转化对胰腺癌转移并非必需，但可诱导其产生化疗耐药性。
Nature. 2015 Nov 26;527(7579):525-530. doi: 10.1038/nature16064. Epub 2015 Nov 11.
6
Distinct EMT programs control normal mammary stem cells and tumour-initiating cells.不同的上皮-间质转化程序控制正常乳腺干细胞和肿瘤起始细胞。
Nature. 2015 Sep 10;525(7568):256-60. doi: 10.1038/nature14897. Epub 2015 Sep 2.
7
A historical overview of protein kinases and their targeted small molecule inhibitors.蛋白激酶及其靶向小分子抑制剂的历史概述。
Pharmacol Res. 2015 Oct;100:1-23. doi: 10.1016/j.phrs.2015.07.010. Epub 2015 Jul 21.
8
Tumorigenesis: it takes a village.肿瘤发生：需要一个村庄。
Nat Rev Cancer. 2015 Aug;15(8):473-83. doi: 10.1038/nrc3971. Epub 2015 Jul 2.
9
EMT, CTCs and CSCs in tumor relapse and drug-resistance.肿瘤复发和耐药中的上皮-间质转化、循环肿瘤细胞和癌症干细胞
Oncotarget. 2015 May 10;6(13):10697-711. doi: 10.18632/oncotarget.4037.
10
Mechanisms of disseminated cancer cell dormancy: an awakening field.播散性癌细胞休眠的机制：一个觉醒的领域。
Nat Rev Cancer. 2014 Sep;14(9):611-22. doi: 10.1038/nrc3793. Epub 2014 Aug 14.

Harnessing protein kinase A activation to induce mesenchymal-epithelial programs to eliminate chemoresistant, tumor-initiating breast cancer cells.

作者信息

Gooding Alex J, Schiemann William P

机构信息

Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106.

出版信息

Transl Cancer Res. 2016 Aug;5(Suppl 2):S226-S232. doi: 10.21037/tcr.2016.08.09.

DOI:10.21037/tcr.2016.08.09
PMID:28680830
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5495186/
Abstract
摘要