Harnessing protein kinase A activation to induce mesenchymal-epithelial programs to eliminate chemoresistant, tumor-initiating breast cancer cells.
作者信息
Gooding Alex J, Schiemann William P
机构信息
Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106.
出版信息
Transl Cancer Res. 2016 Aug;5(Suppl 2):S226-S232. doi: 10.21037/tcr.2016.08.09.
Abstract
摘要
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Design of Next-Generation G Protein-Coupled Receptor Drugs: Linking Novel Pharmacology and In Vivo Animal Models.下一代 G 蛋白偶联受体药物的设计：新型药理学与体内动物模型的关联。
Annu Rev Pharmacol Toxicol. 2016;56:535-59. doi: 10.1146/annurev-pharmtox-011613-140012.
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Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance.上皮-间质转化并非肺转移所必需，但会导致化疗耐药。
Nature. 2015 Nov 26;527(7579):472-6. doi: 10.1038/nature15748. Epub 2015 Nov 11.
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Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer.上皮-间质转化对胰腺癌转移并非必需，但可诱导其产生化疗耐药性。
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