Djiambou-Nganjeu Herbert
Division of Hepato-gastroenterology of Internal Medicine Department at Lviv Regional Clinical Hospital, Danylo Halytsky Lviv National Medical University, Ukraine.
J Transl Int Med. 2017 Mar 31;5(1):64-67. doi: 10.1515/jtim-2017-0013. eCollection 2017 Mar.
Liver cirrhosis is a worldwide gastroenterological condition, characterized by a slow, progressive and irreversible replacement of liver cells by fibrous tissue (scar) that prevents liver function. This condition often leads to the development of other syndromes. Cardiac complications can be indicated through abnormal QTc interval and arrhythmias, thereby their analysis aids in the prevention of cardiovascular events. Most cirrhotic cases have abnormal laboratory values (bilirubin, albumin, AST, ALT, AST/ALT, INR) indicating the presence of concomitant infection, inflammation and coagulopathy. In this case report, the usage Halstead-Reitan and Child-Pugh score helped in the assessment of the status of deterioration of brain. The knowledge of liver cirrhosis aetiologies help to determine the predisposition to development of hepatic encephalopathy and cardiomyopathy. The different values of liver enzymes and other blood laboratory analyses indicated the level of liver damage and poor prognosis.
肝硬化是一种全球性的胃肠病，其特征是肝细胞被纤维组织（瘢痕）缓慢、渐进且不可逆地替代，从而妨碍肝功能。这种病症常常会引发其他综合征。心脏并发症可通过异常的QTc间期和心律失常来表明，因此对它们的分析有助于预防心血管事件。大多数肝硬化病例的实验室值（胆红素、白蛋白、谷草转氨酶、谷丙转氨酶、谷草转氨酶/谷丙转氨酶、国际标准化比值）异常，表明存在合并感染、炎症和凝血病。在本病例报告中，使用霍尔斯特德-赖坦神经心理成套测验和Child-Pugh评分有助于评估脑功能恶化状况。对肝硬化病因的了解有助于确定发生肝性脑病和心肌病的易感性。肝酶的不同数值以及其他血液实验室分析结果表明了肝损伤程度和预后不良。
