Humphries T J, Castell D O
Dig Dis Sci. 1981 Feb;26(2):129-32. doi: 10.1007/BF01312229.
It has been suggested that enhanced esophageal peristalsis may be an additional reason for the therapeutic effect of oral bethanechol (B) in reflux patients and for the improved acid clearing seen with B. This study was designed to determine the effect of oral B on various parameters of esophageal peristalsis. Healthy young adult males were studied with an intraesophageal transducer assembly. Amplitude, dp/dt, and velocity profiles for the smooth muscle portion of the esophagus were produced. Oral B, 25 mg, produced a significant increase (P less than 0.05) in amplitude in the distal esophagus from 15 to 45 min after drug administration. The effect on dp/dt was similar but not as marked. Oral bethanechol produced decreases in velocity at all points, reaching significance (P less than 0.05) at the most distal measuring site, 30 and 45 min after injection. Oral B produces a stronger but slower, perhaps more efficient, progression of the peristaltic wave in normal humans. Our findings may explain improved acid clearance found with this agent.
有人提出，食管蠕动增强可能是口服氨甲酰甲胆碱（B）对反流患者产生治疗效果以及出现B所带来的改善酸清除效果的另一个原因。本研究旨在确定口服B对食管蠕动各项参数的影响。使用食管内换能器组件对健康年轻成年男性进行研究。生成了食管平滑肌部分的振幅、dp/dt和速度曲线。口服25毫克B后，给药后15至45分钟，食管远端的振幅显著增加（P<0.05）。对dp/dt的影响相似但不那么明显。口服氨甲酰甲胆碱在所有测量点的速度均降低，在注射后30分钟和45分钟时，最远端测量部位的速度降低达到显著水平（P<0.05）。口服B在正常人体内产生更强但更慢、可能更有效的蠕动波推进。我们的研究结果可能解释了该药物所带来的改善酸清除效果。
