Hightower Jane M, Dalessandri Kathie M, Pope Karl, Hernández Germán T
a California Pacific Medical Center , San Francisco , California , USA.
b Senior Surgeon-Scientist, Independent , Point Reyes Station , California , USA.
J Am Coll Nutr. 2017 Aug;36(6):455-461. doi: 10.1080/07315724.2017.1320951. Epub 2017 Jul 6.
Myofascial pain that has been associated with cancer and increased risk of morbidity and mortality in cancer patients is intrinsically associated with low magnesium and low 25-hydroxyvitamin D (25(OH)D). Therefore, this physical finding was used as a clinical diagnostic proxy.
The objective of this study was to assess the association and prevalence of disease in individuals with myofascial pain and low 25(OH)D in a county with low magnesium in the drinking water.
This is a retrospective cross-sectional study of a chart review of 269 subjects to assess subjects presenting with myofascial pain (assessed by tender trigger points) and 25(OH)D concentrations below 30 ng/mL or a history of 25(OH)D deficiency compared to those without these exposures.
The association between the exposure of low 25(OH)D levels and myofascial pain was compared to all cancers, colon polyps, and tendon ruptures. The odds of having cancer with the combined exposures was 10.14 times the odds of not having either exposure (95% confidence interval [CI], 5.08, 20.25, p < 0.001). For adenomatous colon polyps, the odds ratio (OR) was 7.24 (95% CI, 3.83, 13.69, p < 0.001), and for tendon rupture, the OR was 8.65 (95% CI, 3.76, 19.94, p < 0.001). Of 80 subjects who had both myofascial pain and 25(OH)D less than 30 ng/mL, 74 were tested for red blood cell (RBC) magnesium. Half of those subjects had RBC magnesium concentrations < 4.6 mg/dL, and 23% had levels below the reference range (4.0-6.4 mg/dL).
Myofascial pain as assessed by tender trigger points and 25(OH)D deficiency showed a significant association with cancer, adenomatous colon polyps, and tendon rupture. Further studies to verify these results are needed, especially in areas where there is low magnesium in the drinking water.
肌筋膜疼痛与癌症相关，且癌症患者的发病率和死亡率风险增加，这与低镁和低25-羟基维生素D（25(OH)D）内在相关。因此，这一身体检查结果被用作临床诊断指标。
本研究的目的是评估饮用水中镁含量低的某县患有肌筋膜疼痛和低25(OH)D的个体中疾病的关联和患病率。
这是一项回顾性横断面研究，对269名受试者的病历进行审查，以评估出现肌筋膜疼痛（通过压痛点评估）且25(OH)D浓度低于30 ng/mL或有25(OH)D缺乏病史的受试者，并与未接触这些因素的受试者进行比较。
将低25(OH)D水平暴露与肌筋膜疼痛之间的关联与所有癌症、结肠息肉和肌腱断裂进行比较。同时暴露于两者的患癌几率是未暴露于任何一种因素的患癌几率的10.14倍（95%置信区间[CI]，5.08，20.25，p<0.001）。对于腺瘤性结肠息肉，比值比（OR）为7.24（95%CI，3.83，13.69，p<0.001），对于肌腱断裂，OR为8.65（95%CI，3.76，19.94，p<0.001）。在80名既有肌筋膜疼痛又有25(OH)D低于30 ng/mL的受试者中，74人检测了红细胞（RBC）镁含量。这些受试者中有一半的RBC镁浓度<4.6 mg/dL，23%的人低于参考范围（4.0 - 6.4 mg/dL）。
通过压痛点评估的肌筋膜疼痛和25(OH)D缺乏与癌症、腺瘤性结肠息肉和肌腱断裂存在显著关联。需要进一步研究以验证这些结果，尤其是在饮用水中镁含量低的地区。
