搭建细胞与分子结构生物学之间的桥梁。
Building bridges between cellular and molecular structural biology.
作者信息
Patwardhan Ardan, Brandt Robert, Butcher Sarah J, Collinson Lucy, Gault David, Grünewald Kay, Hecksel Corey, Huiskonen Juha T, Iudin Andrii, Jones Martin L, Korir Paul K, Koster Abraham J, Lagerstedt Ingvar, Lawson Catherine L, Mastronarde David, McCormick Matthew, Parkinson Helen, Rosenthal Peter B, Saalfeld Stephan, Saibil Helen R, Sarntivijai Sirarat, Solanes Valero Irene, Subramaniam Sriram, Swedlow Jason R, Tudose Ilinca, Winn Martyn, Kleywegt Gerard J
机构信息
Cellular Structure and 3D Bioimaging, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
Visualization Sciences Group, FEI, Mérignac, France.
出版信息
Elife. 2017 Jul 6;6:e25835. doi: 10.7554/eLife.25835.
The integration of cellular and molecular structural data is key to understanding the function of macromolecular assemblies and complexes in their in vivo context. Here we report on the outcomes of a workshop that discussed how to integrate structural data from a range of public archives. The workshop identified two main priorities: the development of tools and file formats to support segmentation (that is, the decomposition of a three-dimensional volume into regions that can be associated with defined objects), and the development of tools to support the annotation of biological structures.
整合细胞和分子结构数据是在体内环境中理解大分子组装体和复合物功能的关键。在此，我们报告了一个研讨会的成果，该研讨会讨论了如何整合来自一系列公共档案的结构数据。研讨会确定了两个主要优先事项：开发支持分割的工具和文件格式（即将三维体积分解为可与特定对象相关联的区域），以及开发支持生物结构注释的工具。
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