MCC-西班牙病例对照研究中的身体活动领域与胃腺癌风险
Physical activity domains and risk of gastric adenocarcinoma in the MCC-Spain case-control study.
作者信息
Huerta José M, Chirlaque María Dolores, Molina Antonio J, Amiano Pilar, Martín Vicente, Fernández-Villa Tania, Pérez-Gómez Beatriz, Moreno Víctor, Burgui Rosana, Gómez-Acebo Inés, Ramos-Lora Manuel, Fernández-Tardón Guillermo, Peiró Rosana, Olmedo-Requena Rocío, Pollán Marina, Kogevinas Manolis, Castaño-Vinyals Gemma, Aragonés Nuria
机构信息
Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain.
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
出版信息
PLoS One. 2017 Jul 6;12(7):e0179731. doi: 10.1371/journal.pone.0179731. eCollection 2017.
BACKGROUND
Evidence for a protective role of physical activity against development of stomach cancer is yet inconclusive. We studied the association of domain-specific physical activity and the risk of gastric adenocarcinoma (GAC), by site and histology, in the MCC-Spain case-control study.
METHODS
428 histologically confirmed GAC cases (67% men) including the gastro-esophageal region and 3225 controls were included. Cases were recruited in hospitals from 10 different Spanish regions, whereas population controls were randomly selected within the respective hospitals' catchment areas. A physical activity (PA) questionnaire was used to gather information on household and recreational activities, allowing estimation of PA volume (in metabolic equivalents (MET)-min/week). Participants also reported the intensity of working PA and daily sitting time. Questionnaire data on diet, lifestyles and clinical variables including Helicobacter pylori serology were available. Adjusted odds ratios (OR) of GAC were estimated for domains of physical activity, stratifying by sex, site (cardia vs. non-cardia), and Lauren classification (intestinal vs. diffuse).
RESULTS
Household physical activity (HPA) showed a strong inverse association with GAC, observed for both cardia and non-cardia tumours. Risk of overall gastric cancer was 50% lower risk among participants in the highest HPA category (OR = 0.50, 95%CI: 0.38, 0.66). Recreational physical activity (RPA) was also associated with lower overall GAC risk (OR = 0.68, 95% CI: 0.52, 0.88), particularly at moderate levels of intensity such as walking (OR = 0.61, 95% CI: 0.46, 0.79). The protective effect of RPA was strongest for non-cardia tumours. Sedentary time was not related to GAC risk (p-trend = 0.392), but the potential protective effect of RPA was restricted to non-sedentary participants.
CONCLUSIONS
Both household and recreational physical activities were independently related to lower GAC risk in the MCC-Spain study.
背景
体育活动对胃癌发生具有保护作用的证据尚无定论。在西班牙MCC病例对照研究中，我们按部位和组织学研究了特定领域体育活动与胃腺癌（GAC）风险之间的关联。
方法
纳入428例经组织学确诊的GAC病例（67%为男性），包括胃食管区域，以及3225例对照。病例来自西班牙10个不同地区的医院，而人群对照是在各医院的服务区域内随机选取的。使用一份体育活动（PA）问卷收集有关家务和娱乐活动的信息，以估计PA量（以代谢当量（MET）-分钟/周计）。参与者还报告了工作PA强度和每日久坐时间。可获取关于饮食、生活方式和临床变量（包括幽门螺杆菌血清学）的问卷数据。按性别、部位（贲门与非贲门）和劳伦分类（肠型与弥漫型）分层，估计体育活动各领域GAC的调整比值比（OR）。
结果
家务体育活动（HPA）与GAC呈强烈负相关，贲门和非贲门肿瘤均如此。HPA最高类别参与者的总体胃癌风险降低50%（OR = 0.50，95%CI：0.38，0.66）。娱乐体育活动（RPA）也与总体GAC风险降低相关（OR = 0.68，95%CI：0.52，0.88），尤其是在中等强度水平，如步行（OR = 0.61，95%CI：0.46，0.79）。RPA对非贲门肿瘤的保护作用最强。久坐时间与GAC风险无关（p趋势 = 0.392），但RPA的潜在保护作用仅限于非久坐参与者。
结论
在西班牙MCC研究中，家务和娱乐体育活动均与较低的GAC风险独立相关。
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