Castaño-Vinyals Gemma, Aragonés Nuria, Pérez-Gómez Beatriz, Martín Vicente, Llorca Javier, Moreno Victor, Altzibar Jone M, Ardanaz Eva, de Sanjosé Sílvia, Jiménez-Moleón José Juan, Tardón Adonina, Alguacil Juan, Peiró Rosana, Marcos-Gragera Rafael, Navarro Carmen, Pollán Marina, Kogevinas Manolis
Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
Environmental and Cancer Epidemiology Unit, National Center of Epidemiology, Instituto de Salud Carlos III, Madrid, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; IIS Puerta de Hierro, Majadahonda, Spain.
Gac Sanit. 2015 Jul-Aug;29(4):308-15. doi: 10.1016/j.gaceta.2014.12.003. Epub 2015 Jan 19.
We present the protocol of a large population-based case-control study of 5 common tumors in Spain (MCC-Spain) that evaluates environmental exposures and genetic factors.
Between 2008-2013, 10,106 subjects aged 20-85 were enrolled in 23 hospitals and primary care centres in 12 Spanish provinces including 1,112 cases with a new diagnosis of prostate cancer, 1,738 of breast cancer, 2,140 of colorectal cancer, 459 of gastro-oesophageal cancer, 559 cases with chronic lymphocytic leukaemia and 4,098 population controls frequency matched to cases by age, sex and region of residence. Participation rates ranged from 57% (stomach cancer) to 87% (CLL cases) and from 30% to 77% in controls. Participants completed a face-to-face computerized interview on sociodemographic factors, environmental exposures, occupation, medication, lifestyle, and personal and family medical history. In addition, participants completed a self-administered food-frequency questionnaire and telephone interviews. Blood samples were collected from 76% of participants while saliva samples were collected in CLL cases and participants refusing blood extractions. Clinical information was recorded for cases and paraffin blocks and/or fresh tumor samples are available in most collaborating hospitals. Genotyping was done through an exome array enriched with genetic markers in specific pathways. Multiple analyses are planned to assess the association of environmental, personal and genetic risk factors for each tumor and to identify pleiotropic effects.
This study, conducted within the Spanish Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), is a unique initiative to evaluate etiological factors for common cancers and will promote cancer research and prevention in Spain.
我们介绍一项在西班牙开展的针对5种常见肿瘤的大型人群病例对照研究（MCC - 西班牙研究）的方案，该研究评估环境暴露因素和遗传因素。
在2008年至2013年期间，10106名年龄在20至85岁之间的受试者在西班牙12个省份的23家医院和初级保健中心入组，其中包括1112例新诊断的前列腺癌患者、1738例乳腺癌患者、2140例结直肠癌患者、459例胃食管癌患者、559例慢性淋巴细胞白血病患者以及4098名按年龄、性别和居住地区与病例进行频率匹配的人群对照。参与率从57%（胃癌）到87%（慢性淋巴细胞白血病病例）不等，对照组的参与率从30%到77%不等。参与者完成了一项关于社会人口学因素、环境暴露、职业、用药情况、生活方式以及个人和家族病史的面对面计算机化访谈。此外，参与者还完成了一份自行填写的食物频率问卷和电话访谈。76%的参与者采集了血样，慢性淋巴细胞白血病病例和拒绝采血的参与者采集了唾液样本。记录了病例的临床信息，大多数合作医院都有石蜡块和/或新鲜肿瘤样本。基因分型通过在特定途径中富集遗传标记的外显子阵列进行。计划进行多项分析，以评估每种肿瘤的环境、个人和遗传风险因素之间的关联，并识别多效性效应。
这项在西班牙流行病学与公共卫生生物医学研究联盟（CIBERESP）内部开展的研究，是评估常见癌症病因因素的一项独特举措，将推动西班牙的癌症研究与预防工作。
