Department of Medical Laboratory Science, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Department of Medical Laboratory Science, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Cancer Lett. 2023 Mar 1;556:216076. doi: 10.1016/j.canlet.2023.216076. Epub 2023 Jan 29.
Immunometabolism, a branch of biology describing the link between immunity and metabolism, is an emerging topic in cancer immunology. It is currently well accepted that B cells and tertiary lymph structures formed by them are associated with favorable outcomes when patients undergo cancer immunotherapy. Understanding the determinants of B-cell fate and function in cancer patients is necessary for improving cancer immunotherapy. Accumulating evidence points to the tumor microenvironment being a critical metabolic hurdle to an efficient antitumor B-cell response. At the same time, several B-cell-derived metabolites have recently been reported to inhibit anticancer immunity. In this literature review, key B-cell immunometabolism studies and the metabolic life of B cells were summarized. Then, we discussed the intrinsic metabolic pathways of B cells themselves and how the tumor microenvironment and B cells in tumors metabolically influence each other. Finally, we pointed out key questions to provide some inspiration for further study of the role of B-cell immunometabolism in the antitumor immune response.
免疫代谢是描述免疫和代谢之间联系的生物学分支，是癌症免疫学中的一个新兴课题。目前人们普遍认为，在癌症免疫治疗中，B 细胞及其形成的三级淋巴结构与良好的预后相关。了解癌症患者中 B 细胞命运和功能的决定因素，对于改善癌症免疫治疗是必要的。越来越多的证据表明，肿瘤微环境是抗肿瘤 B 细胞反应的一个关键代谢障碍。同时，最近有报道称，几种 B 细胞衍生的代谢物可抑制抗肿瘤免疫。在这篇文献综述中，总结了关键的 B 细胞免疫代谢研究和 B 细胞的代谢生命。然后，我们讨论了 B 细胞自身的内在代谢途径，以及肿瘤微环境和肿瘤中的 B 细胞如何相互影响代谢。最后，我们指出了关键问题，为进一步研究 B 细胞免疫代谢在抗肿瘤免疫反应中的作用提供了一些启示。
