Fominykh Vera, Shevtsova Tatyana, Arzumanian Narine, Brylev Lev
Bujanov Moscow City Clinical Hospital, Multiple Sclerosis Center № 1, Moscow, Russia; Institute of Higher Nervous Activity and Neurophysiology RAS, Moscow, Russia.
Department of Internal Medicine, Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia.
J Clin Neurosci. 2017 Oct;44:230-233. doi: 10.1016/j.jocn.2017.06.031. Epub 2017 Jul 3.
Multiple sclerosis is a chronic demyelinating disorder of the central nervous system. There are many cases of multiple sclerosis - like syndrome and demyelinating disorders in systemic lupus erythematosus, Sjogren disease, Behcet disease and other autoimmune conditions. Coexistence of ankylosing spondylitis and multiple sclerosis usually is rare but in this article we report 4 Russian patients with concomitant multiple sclerosis and ankylosing spondylitis diseases. None of these patients received anti-tumor necrosis factor alpha therapy prior to diagnosis of multiple sclerosis. Pathogenesis, diagnostic and treatment challenges are discussed.
多发性硬化是一种中枢神经系统的慢性脱髓鞘疾病。在系统性红斑狼疮、干燥综合征、白塞病和其他自身免疫性疾病中，有许多多发性硬化样综合征和脱髓鞘疾病的病例。强直性脊柱炎与多发性硬化并存通常很少见，但在本文中，我们报告了4例同时患有多发性硬化和强直性脊柱炎的俄罗斯患者。这些患者在诊断为多发性硬化之前均未接受抗肿瘤坏死因子α治疗。本文还讨论了其发病机制、诊断和治疗挑战。
