Whitehouse P J, Muramoto O, Troncoso J C, Kanazawa I
Neurology. 1986 Feb;36(2):193-7. doi: 10.1212/wnl.36.2.193.
We used in vitro receptor autoradiography to study four cases of olivopontocerebellar atrophy (OPCA) and three age- and postmortem delay-matched controls. In OPCA, benzodiazepine receptors were unchanged in cerebellar cortex but increased in the dentate nucleus, perhaps related to loss of Purkinje cell or brainstem afferents. Muscimol binding was reduced primarily in the granule cell layer. The density of muscarinic cholinergic receptors was reduced in molecular and granule cell layers, but appeared increased in the dentate.
我们使用体外受体放射自显影技术研究了4例橄榄体脑桥小脑萎缩（OPCA）患者以及3例年龄和死后延迟时间相匹配的对照者。在OPCA患者中，小脑皮质中的苯二氮䓬受体未发生变化，但齿状核中的受体增加，这可能与浦肯野细胞或脑干传入神经的丧失有关。蝇蕈醇结合主要在颗粒细胞层减少。毒蕈碱胆碱能受体的密度在分子层和颗粒细胞层减少，但在齿状核中似乎增加。
