Penney J B, Young A B
Neurology. 1982 Dec;32(12):1391-5. doi: 10.1212/wnl.32.12.1391.
We studied gamma-aminobutyric acid (GABA), benzodiazepine, and muscarinic cholinergic receptor-binding by quantitative autoradiography. In coronal sections from the brain of a patient with Huntington disease, binding for all three receptors in caudate and putamen was lower than control values. Binding to GABA and benzodiazepine receptors was increased in lateral and medial pallidum and decreased in ventrolateral thalamus. Muscarinic cholinergic receptors were markedly decreased in pallidum but not thalamus. The findings suggest that loss of striatal afferents to both segments of pallidum results in GABA and benzodiazepine receptor supersensitivity, and support the utility of quantitative autoradiography for receptor studies in human postmortem material.
我们通过定量放射自显影术研究了γ-氨基丁酸（GABA）、苯二氮䓬和毒蕈碱胆碱能受体结合情况。在一名亨廷顿病患者大脑的冠状切片中，尾状核和壳核中所有三种受体的结合均低于对照值。外侧和内侧苍白球中GABA和苯二氮䓬受体的结合增加，而腹外侧丘脑的结合减少。苍白球中的毒蕈碱胆碱能受体明显减少，但丘脑未减少。这些发现表明，苍白球两个节段的纹状体传入纤维丧失导致GABA和苯二氮䓬受体超敏反应，并支持定量放射自显影术在人类尸检材料受体研究中的实用性。
