Czuczwar S J, Cavalheiro E A, Turski L, Turski W A, Kleinrok Z
Neurosci Res. 1985 Oct;3(1):86-90. doi: 10.1016/0168-0102(85)90041-0.
2-Amino-5-phosphonopentanoic acid (100 and 200 mg/kg) and 2-amino-7-phosphonoheptanoic acid (50-200 mg/kg i.p.) significantly elevated the threshold for maximal electroconvulsions in mice, the latter being more effective in this respect. In contrast, neither alpha-aminoadipic acid nor L-glutamic acid diethyl ester (up to 200 and 400 mg/kg, respectively) offered any protection. The present results add further evidence to support the importance of the blockade of N-methyl-D-aspartic acid receptor-mediated events in the suppression of seizure activity.
2-氨基-5-膦酰基戊酸（100和200毫克/千克）以及2-氨基-7-膦酰基庚酸（腹腔注射50 - 200毫克/千克）能显著提高小鼠最大电惊厥的阈值，后者在这方面更有效。相比之下，α-氨基己二酸和L-谷氨酸二乙酯（分别高达200和400毫克/千克）均未提供任何保护作用。目前的结果进一步证明了阻断N-甲基-D-天冬氨酸受体介导的事件在抑制癫痫发作活动中的重要性。
