Colton C A, Colton J S
Can J Physiol Pharmacol. 1985 May;63(5):519-21. doi: 10.1139/y85-090.
The effectiveness of several excitatory amino acid antagonists to delay or block seizures induced by oxygen at high pressure was examined in mice. Of the antagonists tested, namely, L-proline, DL-alpha-aminoadipate, DL-2-amino-5-phosphonovalerate, and L-glutamic acid diethyl ester, DL-2-amino-5-phosphonovalerate was the most effective in delaying or preventing seizures. L-Glutamic acid diethylester was also effective but at significantly higher doses, which were also associated with marked sedation.
在小鼠中检测了几种兴奋性氨基酸拮抗剂延缓或阻断高压氧诱发癫痫发作的效果。在所测试的拮抗剂中，即L-脯氨酸、DL-α-氨基己二酸、DL-2-氨基-5-磷酸戊酸和L-谷氨酸二乙酯，DL-2-氨基-5-磷酸戊酸在延缓或预防癫痫发作方面最为有效。L-谷氨酸二乙酯也有效，但所需剂量显著更高，且还伴有明显的镇静作用。
