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它是克罗恩病谱系中的触发因素吗?

Is the Trigger in the Crohn's Disease Spectrum?

作者信息

Oken Harry A, Saleeb Paul G, Redfield Robert R, Schimpff Stephen C

机构信息

University of Maryland School of Medicine, Baltimore, Maryland.

出版信息

Open Forum Infect Dis. 2017 May 18;4(3):ofx104. doi: 10.1093/ofid/ofx104. eCollection 2017 Summer.

DOI:10.1093/ofid/ofx104
PMID:28685154
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5493936/
Abstract

We present and discuss a 30-month investigation of a patient that presented with abdominal pain, postprandial diarrhea, bloating, and night sweats and was treated for Crohn's disease without significant improvement. The patient underwent an ileocecetomy with removal of an atonic segment with resolution of functional gastrointestinal symptoms, but profound night sweats continued postoperatively. The patient was presumptively treated for a mixed mycobacterial infection, blood cultures later grew (MAP), and she improved over time. We discuss MAP and its possible relationship to Crohn's disease.

摘要

我们展示并讨论了一项针对一名患者进行的为期30个月的调查。该患者出现腹痛、餐后腹泻、腹胀和盗汗症状,曾接受克罗恩病治疗但无明显改善。患者接受了回盲部切除术,切除了一段无张力肠段,功能性胃肠道症状得到缓解,但术后仍有严重盗汗。患者被初步诊断为混合分枝杆菌感染并接受治疗,后来血培养长出(鸟分枝杆菌),随着时间推移她的病情有所改善。我们讨论了鸟分枝杆菌及其与克罗恩病可能存在的关系。

相似文献

1
Is the Trigger in the Crohn's Disease Spectrum?它是克罗恩病谱系中的触发因素吗?
Open Forum Infect Dis. 2017 May 18;4(3):ofx104. doi: 10.1093/ofid/ofx104. eCollection 2017 Summer.
2
Detection and Isolation of Mycobacterium avium subspecies paratuberculosis from intestinal mucosal biopsies of patients with and without Crohn's disease in Sardinia.从撒丁岛克罗恩病患者和非克罗恩病患者的肠道黏膜活检样本中检测和分离副结核分枝杆菌鸟亚种。
Am J Gastroenterol. 2005 Jul;100(7):1529-36. doi: 10.1111/j.1572-0241.2005.41415.x.
3
Review article: Mycobacterium avium subsp. paratuberculosis as one cause of Crohn's disease.综述文章:副结核分枝杆菌作为克罗恩病的病因之一
Aliment Pharmacol Ther. 2001 Mar;15(3):337-46. doi: 10.1046/j.1365-2036.2001.00933.x.
4
Molecular evidence for Mycobacterium avium subspecies paratuberculosis (MAP) in Crohn's disease correlates with enhanced TNF-alpha secretion.克罗恩病中副结核分枝杆菌(MAP)的分子证据与肿瘤坏死因子-α(TNF-α)分泌增加相关。
Dig Liver Dis. 2007 May;39(5):445-51. doi: 10.1016/j.dld.2006.12.006. Epub 2007 Feb 21.
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Presence and characterization of Mycobacterium avium subspecies paratuberculosis from clinical and suspected cases of Crohn's disease and in the healthy human population in India.印度克罗恩病临床及疑似病例和健康人群中副结核分枝杆菌亚种的存在及其特征分析
Int J Infect Dis. 2008 Mar;12(2):190-7. doi: 10.1016/j.ijid.2007.06.008. Epub 2007 Oct 2.
6
A case-control study of drinking water and dairy products in Crohn's Disease--further investigation of the possible role of Mycobacterium avium paratuberculosis.一项关于克罗恩病患者饮用水和乳制品的病例对照研究——对副结核分枝杆菌可能作用的进一步调查
Am J Epidemiol. 2007 Apr 1;165(7):776-83. doi: 10.1093/aje/kwk067. Epub 2007 Jan 19.
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Mycobacterium paratuberculosis as a cause of Crohn's disease.副结核分枝杆菌作为克罗恩病的一个病因
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Culture of Mycobacterium avium subspecies paratuberculosis from the blood of patients with Crohn's disease.从克罗恩病患者血液中培养副结核分枝杆菌鸟亚种。
Lancet. 2004;364(9439):1039-44. doi: 10.1016/S0140-6736(04)17058-X.
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Mycobacterium paratuberculosis and Mycobacterium avium subsp. silvaticum DNA cannot be detected by PCR in Crohn's disease tissue.在克罗恩病组织中,通过聚合酶链反应无法检测到副结核分枝杆菌和鸟分枝杆菌亚种的DNA。
Gastroenterol Clin Biol. 1998 Aug-Sep;22(8-9):675-8.
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Concurrent Resolution of Chronic Diarrhea Likely Due to Crohn's Disease and Infection with .可能由克罗恩病和……感染导致的慢性腹泻的同时解决
Front Med (Lausanne). 2016 Oct 27;3:49. doi: 10.3389/fmed.2016.00049. eCollection 2016.

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本文引用的文献

1
Detection of viable Mycobacterium avium subspecies paratuberculosis in powdered infant formula by phage-PCR and confirmed by culture.通过噬菌体聚合酶链反应检测婴儿配方奶粉中存活的副结核分枝杆菌亚种,并通过培养进行确认。
Int J Food Microbiol. 2016 Jan 4;216:91-4. doi: 10.1016/j.ijfoodmicro.2015.09.011. Epub 2015 Sep 21.
2
Crohn's disease and the mycobacterioses: a quarter century later. Causation or simple association?克罗恩病与分枝杆菌病:二十五年后。是因果关系还是单纯的关联?
Crit Rev Microbiol. 2012 Feb;38(1):52-93. doi: 10.3109/1040841X.2011.638273.
3
Antimycobacterial therapy for Crohn's disease: a reanalysis.克罗恩病的抗分枝杆菌治疗:一项重新分析
Lancet Infect Dis. 2008 Jun;8(6):344. doi: 10.1016/S1473-3099(08)70104-X.
4
Two-year combination antibiotic therapy with clarithromycin, rifabutin, and clofazimine for Crohn's disease.克拉霉素、利福布汀和氯法齐明联合使用两年治疗克罗恩病。
Gastroenterology. 2007 Jun;132(7):2313-9. doi: 10.1053/j.gastro.2007.03.031. Epub 2007 Mar 21.
5
On the action of 5-amino-salicylic acid and sulfapyridine on M. avium including subspecies paratuberculosis.关于 5-氨基水杨酸和磺胺吡啶对包括副结核病亚种在内的鸟分枝杆菌的作用。
PLoS One. 2007 Jun 13;2(6):e516. doi: 10.1371/journal.pone.0000516.
6
Culture of Mycobacterium avium subspecies paratuberculosis from the blood of patients with Crohn's disease.从克罗恩病患者血液中培养副结核分枝杆菌鸟亚种。
Lancet. 2004;364(9439):1039-44. doi: 10.1016/S0140-6736(04)17058-X.
7
Is Crohn's disease caused by a mycobacterium? Comparisons with leprosy, tuberculosis, and Johne's disease.克罗恩病是由分枝杆菌引起的吗?与麻风病、结核病和副结核的比较。
Lancet Infect Dis. 2003 Aug;3(8):507-14. doi: 10.1016/s1473-3099(03)00724-2.
8
In defense of case reports and case series.为病例报告和病例系列辩护。
Ann Intern Med. 2001 Feb 20;134(4):330-4. doi: 10.7326/0003-4819-134-4-200102200-00017.