Formica Matteo, Divano Stefano, Cavagnaro Luca, Basso Marco, Zanirato Andrea, Formica Carlo, Felli Lamberto
Clinica Ortopedica-IRCCS Azienda Ospedaliera Universitaria San Martino-IST, Istituto Nazionale per la Ricerca sul Cancro, Largo Rosanna Benzi, 10, 16132, GENOVA, GE, Italy.
IRCCS Istituto Ortopedico Galeazzi, Via Riccardo Galeazzi 4, 20161, MILAN, MI, Italy.
J Orthop Traumatol. 2017 Sep;18(3):197-215. doi: 10.1007/s10195-017-0462-y. Epub 2017 Jul 6.
The purpose of this study was to summarize the available evidence about total lumbar disc replacement (TDR), focusing our attention on four main topics: clinical and functional outcomes, comparison with fusion surgery results, rate of complications and influence on sagittal balance.
We systematically searched Pubmed, Embase, Medline, Medscape, Google Scholar and Cochrane library databases in order to answer our four main research questions. Effective data were extracted after the assessment of methodological quality of the trials.
Fifty-nine pertinent papers were included. Clinical and functional scores show statistically significant improvements, and they last at all time points compared to baseline. The majority of the articles show there is no significant difference between TDR groups and fusion groups. The literature shows similar rates of complications between the two surgical procedures.
TDR showed significant safety and efficacy, comparable to lumbar fusion. The major advantages of a lumbar TDR over fusion include maintenance of segmental motion and the restoration of the disc height, allowing patients to find their own spinal balance. Disc arthroplasty could be a reliable option in the treatment of degenerative disc disease in years to come.
II.
本研究的目的是总结关于全腰椎间盘置换术(TDR)的现有证据,重点关注四个主要主题:临床和功能结果、与融合手术结果的比较、并发症发生率以及对矢状面平衡的影响。
我们系统检索了PubMed、Embase、Medline、Medscape、谷歌学术和Cochrane图书馆数据库,以回答我们的四个主要研究问题。在评估试验的方法学质量后提取有效数据。
纳入了59篇相关论文。临床和功能评分显示出统计学上的显著改善,与基线相比在所有时间点均持续存在。大多数文章表明TDR组和融合组之间没有显著差异。文献显示两种手术方法的并发症发生率相似。
TDR显示出显著的安全性和有效性,与腰椎融合术相当。腰椎TDR相对于融合术的主要优点包括维持节段运动和恢复椎间盘高度,使患者能够找到自身的脊柱平衡。椎间盘置换术在未来几年可能是治疗退行性椎间盘疾病的可靠选择。
II级。