2型糖尿病患者细胞外基质生物标志物与心肌功能的关系
Relationship of biomarkers of extracellular matrix with myocardial function in Type 2 diabetes mellitus.
作者信息
Liu Ju-Hua, Chen Yan, Zhen Zhe, Ho Lai-Ming, Tsang Anita, Yuen Michele, Lam Karen, Tse Hung-Fat, Yiu Kai-Hang
机构信息
Division of Cardiology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China.
Department of Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong City, Sichuan Province, China.
出版信息
Biomark Med. 2017 Jul;11(7):569-578. doi: 10.2217/bmm-2017-0044. Epub 2017 Jul 7.
AIM
The study evaluated the relationship of extracellular matrix and renin angiotensin system with myocardial dysfunction in Type 2 diabetes mellitus.
METHODS
All patients underwent resting and exercise echocardiography, including conventional parameters, E/E' ratio, global longitudinal strain and diastolic function reserve index. Plasma matrix metalloproteinase-1, TIMP-1, amino-terminal propeptide of type I and type III procollagen and renin angiotensin system activity were measured.
RESULTS
As patients with diastolic dysfunction had a higher plasma level of TIMP-1 and propeptide of type III procollagen than those with no diastolic dysfunction. After multivariate adjustment, TIMP-1 associated with E/E' (both at rest and stress) and diastolic function reserve index.
CONCLUSION
TIMP-1 is independently associated with myocardial diastolic dysfunction in patients with Type 2 diabetes mellitus.
目的
本研究评估了细胞外基质和肾素血管紧张素系统与2型糖尿病心肌功能障碍之间的关系。
方法
所有患者均接受静息和运动超声心动图检查，包括常规参数、E/E'比值、整体纵向应变和舒张功能储备指数。检测血浆基质金属蛋白酶-1、组织金属蛋白酶抑制因子-1、I型和III型前胶原氨基端前肽以及肾素血管紧张素系统活性。
结果
舒张功能障碍患者的血浆组织金属蛋白酶抑制因子-1和III型前胶原前肽水平高于无舒张功能障碍者。多因素调整后，组织金属蛋白酶抑制因子-1与E/E'（静息和应激时）及舒张功能储备指数相关。
结论
组织金属蛋白酶抑制因子-1与2型糖尿病患者的心肌舒张功能障碍独立相关。
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