Balaraman Ashok Kumar, Altamimi Abdulmalik Saleh Alfawaz, Babu M Arockia, Goyal Kavita, PadmaPriya G, Bansal Pooja, Rajotiya Sumit, Kumar M Ravi, Rajput Pranchal, Imran Mohd, Gupta Gaurav, Thangavelu Lakshmi
Research and Enterprise, University of Cyberjaya, Persiaran Bestari Cyber 11, Cyberjaya, Selangor, 63000, Malaysia.
Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam bin Abdulaziz University, 11942, Al Kharj, Saudi Arabia.
Biogerontology. 2025 Jan 20;26(1):46. doi: 10.1007/s10522-025-10190-6.
Aging is associated with a marked increase in cardiovascular diseases, such as myocardial infarction (MI). Cellular senescence is also a crucial factor in the development of age-related MI. Matrix metalloproteinases (MMPs) interaction with cellular senescence is a critical determinant of MI development and outcomes, most notably in the aged heart. After experiencing a heart attack, senescent cells exhibit a Senescence-Associated Secretory Phenotype (SASP) and are involved in tissue regeneration and chronic inflammation. MMPs are necessary for extracellular matrix proteolysis and have a biphasic effect, promoting early heart healing and detrimental change if overexpressed shortly. This review analyses the complex connection between senescence and MMPs in MI and how it influences elderly cardiac performance. Critical findings suggest that increasing cellular senescence in aged hearts elevates MMP activity and aggravates extended ventricular remodeling and dysfunction. Additionally, we explore potential therapeutics that address MMPs and senescence to enhance old MI patient myocardial performance and regeneration.
衰老与心血管疾病（如心肌梗死，MI）的显著增加有关。细胞衰老也是与年龄相关的心肌梗死发展的关键因素。基质金属蛋白酶（MMPs）与细胞衰老的相互作用是心肌梗死发展和预后的关键决定因素，在老年心脏中尤为明显。心脏病发作后，衰老细胞表现出衰老相关分泌表型（SASP），并参与组织再生和慢性炎症。MMPs是细胞外基质蛋白水解所必需的，具有双相作用，促进早期心脏愈合，但如果短期内过度表达则会产生有害变化。本综述分析了心肌梗死中衰老与MMPs之间的复杂联系及其对老年心脏功能的影响。关键研究结果表明，老年心脏中细胞衰老的增加会提高MMP活性，加剧心室长期重塑和功能障碍。此外，我们还探讨了针对MMPs和衰老的潜在治疗方法，以提高老年心肌梗死患者的心肌性能和再生能力。
