Department of Chemistry, California State University Fresno, 2555 E. San Ramon Avenue, M/S SB70, Fresno, CA 93740, United States.
Curr Med Chem. 2019;26(17):3042-3067. doi: 10.2174/0929867324666170705112644.
Various exciting immunotherapies aiming to address immune deficiency induced by tumor and treatment hold promise in improving the quality of life and survival rate of cancer patients. It is thus becoming an important and rewarding arena to develop some appropriate immune modulators for cancer prevention and/or treatment. Exploitation of natural products-based immune modulators is of particular imperative because the potential of numerous traditional herbal medicines and edible mushrooms in boosting human immune system has long been verified by folklore practices. This review summarizes the immune modulations of various herbal medicines and edible mushrooms, their crude extracts, and/or key chemical components that have been, at least partly, associated with their cancer management. This article also tabulates the origin of species, key chemical components, and clinical studies of these herbal medicines and edible mushrooms.
各种令人兴奋的免疫疗法旨在解决肿瘤引起的免疫缺陷和治疗，有望提高癌症患者的生活质量和生存率。因此，开发一些合适的免疫调节剂用于癌症的预防和/或治疗成为一个重要且有回报的领域。利用基于天然产物的免疫调节剂具有特别的必要性，因为许多传统草药和食用蘑菇在增强人体免疫系统方面的潜力早已被民间实践所证实。本综述总结了各种草药和食用蘑菇及其粗提取物和/或关键化学成分的免疫调节作用，这些草药和食用蘑菇的免疫调节作用至少部分与它们的癌症管理有关。本文还列出了这些草药和食用蘑菇的物种来源、关键化学成分和临床研究。
