Lack of effect of nizatidine on hepatic drug metabolism in man.
作者信息
Secor J W, Speeg K V, Meredith C G, Johnson R F, Snowdy P, Schenker S
出版信息
Br J Clin Pharmacol. 1985 Dec;20(6):710-3. doi: 10.1111/j.1365-2125.1985.tb05136.x.
Abstract
The effect of nizatidine, a new H2-receptor antagonist, on the hepatic metabolism of three probe drugs was studied in normal volunteers. The drugs studied were chlordiazepoxide and theophylline which are metabolized in part by N-demethylation by the hepatic microsomal cytochrome P-450 system and lorazepam which is conjugated to lorazepam glucuronide. A 7 day course of nizatidine did not interfere with the disposition of any of these therapeutic agents in man.
摘要
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