Desmond P V, Patwardhan R V, Schenker S, Speeg K V
Ann Intern Med. 1980 Aug;93(2):266-8. doi: 10.7326/0003-4819-93-2-266.
We have studied chlordiazepoxide (Librium) disposition and elimination in eight normal subjects before and after 1 week of cimetidine therapy, 300 mg orally four times a day. Cimetidine strikingly impaired the clearance of chlordiazepoxide from plasma, and this was, at least in part, due to decreased demethylation of the drug to N-desmethylchlordiazepoxide. Since the volume of distribution of chlordiazepoxide was not altered by cimetidine, the elimination half-life of chlordiazepoxide was also significantly prolonged by cimetidine therapy.
我们研究了在8名正常受试者中，西咪替丁（300毫克，每日口服4次，共治疗1周）治疗前后氯氮卓（利眠宁）的处置和消除情况。西咪替丁显著损害了氯氮卓从血浆中的清除，这至少部分是由于该药物脱甲基生成N-去甲基氯氮卓的过程减少所致。由于西咪替丁未改变氯氮卓的分布容积，因此西咪替丁治疗也显著延长了氯氮卓的消除半衰期。
