Laboratory of Physiology, Faculty of Medicine of Tunis, University of Tunis El Manar, La Rabta 1007, Tunis, Tunisia; Laboratory of Physiopathology, Food and Biomolecules (LR-17-ES-03), Technology Center of Sidi Thabet, University of Manouba, Tunis, Tunisia.
Laboratory of Experimental Medicine, Faculty of Medicine of Tunis, University of Tunis El Manar, La Rabta 1007, Tunis, Tunisia.
Biomed Pharmacother. 2017 Sep;93:666-673. doi: 10.1016/j.biopha.2017.06.052. Epub 2017 Jul 5.
Pulmonary fibrosis (PF) is a lethal, chronic and progressive respiratory disease leading to interstitial lung damage and serious breathing problems. The pathogenic mechanism involves activation, migration, proliferation and differentiation of fibroblasts into myofibroblats inducing extracellular matrix accumulation that destroy lung parenchyma. Available antifibrotic treatment options are limited to Pirfenidone and Nintedanib that prevent deterioration without an improvement of this disease. The use of plant extracts and natural bioactive compounds for the treatment of PF has been known for more than thirty years in China. Nowadays, phytotherapy has gained a considerable attention in the treatment of PF both in vivo and in vitro using bleomycin (BLM)-induced lung inflammation, oxidative stress and pulmonary fibrosis in rats. In this review, we aimed to focus on the protective effects and the mechanisms of action of several plant extracts described by various research works for the treatment of PF.
肺纤维化（PF）是一种致命的、慢性的、进行性的呼吸系统疾病，导致肺间质损伤和严重的呼吸问题。发病机制涉及成纤维细胞的激活、迁移、增殖和分化为肌成纤维细胞，导致细胞外基质的积累，从而破坏肺实质。现有的抗纤维化治疗选择仅限于吡非尼酮和尼达尼布，它们可以防止病情恶化，但不能改善病情。在中国，用植物提取物和天然生物活性化合物治疗 PF 已经有三十多年的历史了。如今，植物疗法在体内和体外使用博来霉素（BLM）诱导的大鼠肺炎症、氧化应激和肺纤维化方面，对 PF 的治疗引起了相当大的关注。在这篇综述中，我们旨在关注各种研究工作中描述的几种植物提取物的保护作用及其作用机制，用于治疗 PF。
