优化四氟化钛溶液浓度以促进人牙本质再矿化。
Optimizing concentration of titanium tetrafluoride solution for human dentine remineralization.
机构信息
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, China; Department of Preventive Dentistry, College of Stomatology, Xi'an Jiaotong University, Xi'an, China.
Department of Preventive Dentistry, College of Stomatology, Xi'an Jiaotong University, Xi'an, China; Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, China.
出版信息
Arch Oral Biol. 2017 Nov;83:7-12. doi: 10.1016/j.archoralbio.2017.06.021. Epub 2017 Jul 1.
OBJECTIVE
The aim of the present study was to select the optimal concentration of TiF solution to facilitate the remineralization of early dentine caries lesions.
DESIGN
Sixty human dentine specimens were cut and randomly divided into 6 groups (1%, 2%, 3%, 4% TiF groups, 2.712% NaF group and distilled deionized water (DDW) control group). Artificial dentine caries-like lesions were created. After being subjected to fluoride treatment and immersed in remineralizing solution for 2weeks, the specimens were observed by microCT, scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS). Data were analysed using linear regression analysis (P<0.05).
RESULTS
The lesion depths of the specimens treated by 2% TiF solution were statistically less than those of the other groups. Further, the greyscale values of these lesion areas were greater. The 3% and 4% TiF solutions caused further lesion demineralization. The 2.712% NaF solution seemed to be detrimental to remineralization during the experimental time, as the subsurface area remained hypomineralized with a thick precipitation layer on the surface.
CONCLUSIONS
The 2% TiF solution demonstrated better remineralizing potency than did the other treatments.
目的
本研究旨在选择最佳浓度的 TiF 溶液以促进早期牙本质龋损的再矿化。
设计
将 60 个人类牙本质标本切割并随机分为 6 组（1%、2%、3%、4%TiF 组、2.712%NaF 组和蒸馏水（DDW）对照组）。制作人工牙本质龋样病变。经氟化物处理并在再矿化溶液中浸泡 2 周后，用 microCT、扫描电子显微镜（SEM）和 X 射线光电子能谱（XPS）观察标本。采用线性回归分析（P<0.05）进行数据分析。
结果
2%TiF 溶液处理的标本的病变深度明显小于其他组。此外，这些病变区域的灰度值更大。3%和 4%TiF 溶液导致进一步的病变脱矿。2.712%NaF 溶液在实验期间似乎不利于再矿化，因为表面下区域仍然矿化不足，表面有一层厚厚的沉淀层。
结论
2%TiF 溶液的再矿化效果优于其他处理方法。
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