Siegel I, Dudkiewicz A B, Friberg J, Suarez M, Gleicher N
Fertil Steril. 1986 Feb;45(2):273-9. doi: 10.1016/s0015-0282(16)49167-3.
The effects of a serial dilution of linoleic acid on human spermatozoa in whole semen was tested on 21 semen samples obtained from 11 normal volunteers. The minimal concentration of linoleic acid required to stop the movement of at least 75% of the moving sperm ranged from 1 to greater than 100 mg/dl. Fifteen of 21 (71%) of the semen samples were inhibited by added free fatty acids (FFA) concentrations that were less than or close to the physiologic concentration ranges of FFA in blood plasma (1 to 30 mg/dl). The immobilized sperm often formed aggregates similar to those formed by the action of autoantibodies against sperm cells. Preliminary studies conducted on a variety of other FFA have indicated that oleic acid (18/1) was less toxic than linoleic acid (18/2) and that linolenic acid (18/3) was more toxic than linoleic acid. The saturated FFA palmitic acid (16/0) and stearic acid (18/0) at concentrations up to 100 mg/dl showed little or no toxicity to sperm cells. It is suggested that FFA toxicity be included among physiologic factors that affect the motility and spontaneous aggregation of sperm cells.
在从11名正常志愿者获得的21份精液样本上测试了亚油酸系列稀释液对全精液中人类精子的影响。使至少75%的活动精子停止运动所需的亚油酸最低浓度范围为1至大于100mg/dl。21份精液样本中的15份（71%）被添加的游离脂肪酸（FFA）浓度抑制，这些浓度低于或接近血浆中FFA的生理浓度范围（1至30mg/dl）。固定的精子经常形成类似于由抗精子细胞自身抗体作用形成的聚集体。对多种其他FFA进行的初步研究表明，油酸（18/1）的毒性低于亚油酸（18/2），而亚麻酸（18/3）的毒性高于亚油酸。浓度高达100mg/dl的饱和FFA棕榈酸（16/0）和硬脂酸（18/0）对精子细胞几乎没有或没有毒性。有人提出，FFA毒性应被纳入影响精子细胞活力和自发聚集的生理因素之中。
