Center for Autism Research, The Children's Hospital of Philadelphia, 3535 Market Street, Suite 860, Philadelphia, PA, 19104, USA.
Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, Philadelphia, PA, 19104, USA.
J Autism Dev Disord. 2017 Dec;47(12):3682-3691. doi: 10.1007/s10803-017-3206-1.
Recent studies suggest that longstanding findings of abnormal amygdala morphology in ASD may be related to symptoms of anxiety. To test this hypothesis, fifty-three children with ASD (mean age = 11.9) underwent structural MRI and were divided into subgroups to compare those with at least one anxiety disorder diagnosis (n = 29) to those without (n = 24) and to a typically developing control group (TDC; n = 37). Groups were matched on age and intellectual level. The ASD and anxiety group showed decreased right amygdala volume (controlled for total brain volume) relative to ASD without anxiety (p = .04) and TDCs (p = .068). Results suggest that youth with ASD and co-occurring anxiety have a distinct neurodevelopmental trajectory.
最近的研究表明，自闭症谱系障碍（ASD）患者杏仁核形态异常的长期发现可能与焦虑症状有关。为了验证这一假设，对 53 名 ASD 儿童（平均年龄=11.9 岁）进行了结构磁共振成像检查，并将其分为亚组，比较至少有一个焦虑障碍诊断的亚组（n=29）与没有焦虑障碍诊断的亚组（n=24）和一个典型发育对照组（TDC；n=37）。各组在年龄和智力水平上相匹配。与没有焦虑障碍的 ASD 患者（p=0.04）和 TDC 相比，ASD 和焦虑症组的右侧杏仁核体积减少（相对于总脑体积进行控制）（p=0.068）。结果表明，患有 ASD 且伴有共病焦虑的青少年具有独特的神经发育轨迹。
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