Division of Gastroenterology & Hepatology, Beth Israel Deaconess Medical Center, 110 Francis Street, Boston, MA 02125, USA.
Division of Gastroenterology & Hepatology, Beth Israel Deaconess Medical Center, 110 Francis Street, Boston, MA 02125, USA.
Clin Liver Dis. 2017 Aug;21(3):535-542. doi: 10.1016/j.cld.2017.03.008. Epub 2017 Apr 26.
The extrahepatic manifestations of hepatitis C include effects on the central nervous system, which have been associated with the ability of hepatitis C virus (HCV) to replicate in microglial and endothelial cells and the chronic inflammation induced by HCV. HCV can induce impaired neurocognition, which is clinically manifested by impaired quality of life, fatigue, and brain fog. These cognitive defects can be present even in patients with mild histologic HCV and have been confirmed by neurocognitive testing and brain imaging by magnetic resonance spectroscopy. Neurocognitive defects include loss of functioning memory and subtle changes in attention and processing speed.
丙型肝炎的肝外表现包括对中枢神经系统的影响，这与丙型肝炎病毒 (HCV) 在小神经胶质细胞和内皮细胞中的复制能力以及 HCV 引起的慢性炎症有关。HCV 可引起认知障碍，临床上表现为生活质量下降、疲劳和脑雾。即使在组织学上 HCV 轻度的患者中也存在这些认知缺陷，并且已经通过神经认知测试和磁共振波谱的脑成像得到证实。神经认知缺陷包括记忆功能丧失和注意力及处理速度的细微变化。
