Falces-Romero Iker, Troyano-Hernáez Paloma, García-Bujalance Silvia, Baquero-Artigao Fernando, Mellado-Peña María José, García-Rodríguez Julio
Servicio de Microbiología y Parasitología Clínicas, Hospital Universitario La Paz, Madrid, España.
Servicio de Microbiología y Parasitología Clínicas, Hospital Universitario La Paz, Madrid, España; ERN TRANSPLANT-CHILD: European Reference Network of Transplantation in Children (SOT & HSTC), Hospital Universitario La Paz (coordinador).
Enferm Infecc Microbiol Clin (Engl Ed). 2018 Jun-Jul;36(6):357-361. doi: 10.1016/j.eimc.2017.05.006. Epub 2017 Jul 8.
Our main objective was a revision of clinical, microbiological and epidemiological results of Clostridium difficile-associated infection in paediatric patients (2010-2015). We compared the diagnoses performed by detection of toxins in feces and those performed by real-time PCR.
This retrospective study included 82 paediatric patients. Detection of toxigenic C. difficile was performed sequentially, in diarrheal feces and under clinical request.
A total of 39% of the patients were attended at Haematology-oncology Unit and >50% of them had previously received cephalosporins. Fever associated with diarrhea was more frequent in the group of toxin detection, whereas not receiving specific antibiotic treatment was more frequent in the group of positive PCR, without statistically significant differences.
We highlight the presence of C. difficile infection in children under 2years old. A diagnostic testing in selected paediatric patients would be advisable when there is clinical suspicion of infection.
我们的主要目标是对儿科患者艰难梭菌相关感染的临床、微生物学和流行病学结果进行回顾（2010 - 2015年）。我们比较了通过粪便毒素检测和实时聚合酶链反应（PCR）进行的诊断。
这项回顾性研究纳入了82名儿科患者。在腹泻粪便中并根据临床需求依次进行产毒艰难梭菌的检测。
共有39%的患者在血液肿瘤科就诊，其中超过50%的患者此前接受过头孢菌素治疗。毒素检测组中发热伴腹泻更为常见，而PCR阳性组中未接受特定抗生素治疗更为常见，但差异无统计学意义。
我们强调2岁以下儿童存在艰难梭菌感染。当临床怀疑有感染时，对选定的儿科患者进行诊断检测是可取的。
