炎症小体介导体细胞因子在幽门螺杆菌感染中的调控与功能。
Regulation and functions of inflammasome-mediated cytokines in Helicobacter pylori infection.
机构信息
Centre for Innate Immunity and Infectious Diseases, The Hudson Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, Victoria, Australia.
Centre for Innate Immunity and Infectious Diseases, The Hudson Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, Victoria, Australia; Biomedicine Discovery Institute, Department of Microbiology, Monash University, Wellington Road, Clayton, Victoria, Australia.
出版信息
Microbes Infect. 2017 Sep-Oct;19(9-10):449-458. doi: 10.1016/j.micinf.2017.06.005. Epub 2017 Jul 6.
Persistent stomach infection with Helicobacter pylori causes chronic mucosal inflammation (gastritis), which is widely recognized as an essential precursor to gastric cancer. The IL-1 interleukin family cytokines IL-1β and IL-18 have emerged as central mediators of mucosal inflammation. Here, we review the regulation and functions of these cytokines in H. pylori-induced inflammation and carcinogenesis.
幽门螺杆菌持续感染会导致慢性黏膜炎症（胃炎），这被广泛认为是胃癌的重要前期病变。白细胞介素-1 家族细胞因子白细胞介素-1β 和白细胞介素-18 已成为黏膜炎症的重要介质。本文综述了这些细胞因子在幽门螺杆菌诱导的炎症和癌变中的调节和功能。
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